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PHTY2230 Prac Exam (Balance and Vestib) > L13: Anatomy, Physiology of the Vestibular System > Flashcards

L13: Anatomy, Physiology of the Vestibular System Flashcards

1
Q

What is the role of the vestibular system?

A
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2
Q

What happens to the vestibular system and the cerebellum when you are drunk?

A
  • Vestibular system stops working
  • Cerebellum is not listening to vestibular system
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3
Q

What are 4 features that are included in the vestibular system?

A
  1. Peripheral vestibular apparatus
  2. Vestibular components of the 8th cranial nerve
  3. Vestibular nucleii in the brain stem
  4. Central nervous system projections
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4
Q

Where is the peripheral vestibular system?

A
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5
Q

What are the 2 types of labyrinths in the ear?

A
  1. Bony (outer)
  2. Membranous (inner)
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6
Q

What is the purpose of the inner, soft membranous labyrinth?

A
  • Hair follicles/cells
    • Deflect the fluid the other way
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7
Q

What is the inside fluid called?

A

endolymph

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8
Q

What is the outside lfluid called (between the hard shell of the boy and inside the membranous)?

A

perilymph

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9
Q

What are the 5 distinct sensory organs in the peripheral apparatus?

A
  1. 3 semicircular canals (SCC)
    1. Anterior
    2. Horizontal
    3. Posterior orientation
  2. 2 Otolith organs
    1. Utricle
    2. Saccule

Sensory end organs

  • SCCs = Crista Ampullaris
  • Otoliths = Macula
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10
Q

What are the 3 semicircular canals (SCC)?

A
  1. Anterior
  2. Horizontal
  3. Posterior orientation
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11
Q

What are the 2 otolith organs?

A
  1. Utricle
  2. Saccule
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12
Q

What is the sensory end organs of semicircular canals (SCC)?

A

Crista Ampullaris

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13
Q

What is the sensory end organs of Otoliths?

A

Macula

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14
Q

What do the sensory end-organs look like?

A
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15
Q

What is the function of the cupula?

A

Used in diagnosis and rate and direction that the hair cells move

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16
Q

What are otoconia made of?

A

Calcium carbonate crystals stuck on gel-like structure

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17
Q

What is the structure of the crista ampullaris? List 2 features.

A
  1. Hair cells of the ampulla (SCC) rest on a tuft of blood vessels, nerve fibres and supporting cells
  2. A gelatinous membrane called the Cupula overlies each crista
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18
Q

A gelatinous membrane called the _____ overlies each crista

A

Cupula

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19
Q

What is the function of the cupula?

A

Holds them (crista) together and allows the hair cells to move

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20
Q

What is a sterocilia?

A

50-70 small cilia

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21
Q

What is a kinocilium?

A

1 large cilia

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22
Q

Cilia arranged according to size from _____ (shortest/tallest) to _____ (shortest/tallest)

A

shortest; tallest

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23
Q

What is the purpose of the cilia?

A
  • Allows activation of the nerves to be more systematic
  • Depolarise or hyperpolarise
  • Moving one way or the other
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24
Q

Otolithic membrane is similar to ____ of Crista Ampullaris but also has embedded calcium carbonate crystals called ____.

A

cupula; otoconia

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25
Q

What is the otolithic membrane?

A

Otolithic membrane is similar to cupula of Crista Ampullaris but also has embedded calcium carbonate crystals called otoconia

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26
Q

What is the 3 purposes of the otolithic membrane?

A
  1. Increases the mass of the cupula (gel-like systems)
  2. Shearing force on gel like system
  3. Gives constant weight of the hair cells = tells us constantly where we are in space (keeps vestibular system constantly on)
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27
Q

Increased mass of the otolithic membrane means the maculae are sensitive to_____ and _____.

A

gravity; acceleration

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28
Q

How does the displacement of sensory hairs work?

A
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29
Q

Each afferent nerve fibre in the peripheral vestibular apparatus has a baseline ____ rate

A

firing

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30
Q

Deflection of stereocilia toward kinocilium results in a _____ (increase/decrease) in the firing rate of the afferent neuron

A

increase

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31
Q

Deflection of stereocilia away kinocilium results in a _____ (increase/decrease) in the firing rate of the afferent neuron

A

decrease

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32
Q

Hair cells will bend in the ____ (same/opposite) direction to head movement – fluid flow is the _____ (same/opposite). Give an example if the head starts to move to the left.

A

opposite; opposite

  • To the way we move (eg. start turning to the left –> the fluid is going to the right )
  • If suddenly stop –> fluid will go left
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33
Q

When the head is tilted or the body experiences acceleration, the hair cells are ______ and allow detection of the head’s position in space and linear acceleration.

A

deflected

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34
Q

The stimulation of the otolithic maculae is designed for _____ sensitivity.

A

linear

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35
Q

What are 4 characteristics of the vestibular nerve?

A
  1. Vestibular component of 8th cranial nerve (vestibulocochlear nerve)
  2. Afferent nerve only
  3. Travels through the internal auditory canal with the facial nerve and enters the brainstem at the ponto-medullary junction
  4. Debate over whether it is a peripheral or central structure in vestibular pathology – * peripheral for us
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36
Q

What are the 2 splits of the 9th cranial nerve (vestibular nerve)?

A
  1. Superior vestibular
  2. Inferior vestibular
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37
Q

What are 3 structures that the superior vestibular nerve supplies?

A
  1. anterior canal
  2. horizontal canal
  3. utricle
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38
Q

What are 2 structures that the inferior vestibular nerve supplies?

A
  1. posterior canal
  2. saccule
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39
Q

What is the primary processor for central processing?

A

vestibular nuclear complex in brain stem

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40
Q

The primary processor has connections between incoming afferent input from ______ and motor output _____

A

vestibular system; neurons

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41
Q

Central processing occurs concurrently with the processing of other sensory info. This is called _____.

A

Integration

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42
Q

What are the central connections of the vestibular system?

A
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43
Q

What are 4 major vestibular nuclei in the pons and medulla?

A
  1. superior
  2. lateral
  3. medial
  4. inferior
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44
Q

The 4 major vestibular nuclei are located in the ____ and ___

A

medulla; pons

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45
Q

The 4 major vestibular nuclei are connected to the nuclei of the _____, _____ and _____ nerves (CN (- eye muscles- 3, 4 & 6)

A

abducens; trochlear; oculomotor

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46
Q

_____ is what calibrates our vestibular system (stabilises)

A

Vision

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47
Q

You will feel ____ and ____, if vision is fine but vestibular is not

A

imbalanced; giddy

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48
Q

What do the complex feedback loops between the vestibular nuclei in the brainstem and cerebellum look like?

A
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49
Q

What do the afferent input from vestibular system also going directly to cerebellum look like?

A
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50
Q

What is the cerebellum?

A

An adaptive processor

51
Q

What are the 3 functions of the cerebellum?

A
  1. Monitors vestibular performance and readjusts central vestibular processing Refine the movements –> without it –> very clumsy
  2. Calibrates vestibular reflexes
  3. Cerebellar projections have an inhibitory influence Extra signs and symptoms –> neurologists look for these extra symptoms
52
Q

What does the link from the thalamic nuclei and the cortex look like?

A
53
Q

What does the output of vestib nuclei directly to ocular muscles via cranial nerves 3,4 and 6 look like?

A
54
Q

What can the problem be in a poor Marden Pull test?

A
  • Possible vestibular system impairment (don’t know where they are in space)
  • Motor problems (eg. parkinson’s)
55
Q

What does the Excitatory output to Csp and Tsp spinal motor neurones look like?

A
56
Q

What are 4 structures that the verterbro-basilar circulation provides blood supply for?

A
  1. peripheral apparatus
  2. vestibular nerve
  3. brainstem nuclei
  4. cerebellum.
57
Q

If you have whiplash or neck pain, what is the risk?

A

Can have vascular problems

58
Q

If we lose vascular supply to the vestibular system, what are 3 effects?

A

hair cells in the vestibular system

Eg. migraines –> dizziness

Eg. sudden deafness –> medical emergency (very compromised)

59
Q

What is the integration of the vascular and nerve supply to the vestibular apparatus?

A
60
Q

The Vestibulo cochlear artery (posterior vest A) is the _____ (superior/inferior) division of vestib N

A

inferior

61
Q

Vestibulo cochlear artery (anterior vest A) is the ______ (superior/inferior) division of vestib N

A

superior

62
Q

What are semicircular canals?

A

Rate sensors

63
Q

What are 2 functions of the semicircular canals?

A
  1. Provide sensory input about head velocity
  2. Enables the Vestibular ocular reflex (VOR) to generate an eye movement that matches the velocity of the head movement..
64
Q

The alignment of the SCC are characterised by three important spatial arrangements. What are they?

A
  1. Perpendicular arrangement
  2. Coplanar pairing of SCCS
  3. Direction of excitation
65
Q

Each canal plane is perpendicular to the other ____ canals with allows sensing of movement in _____ planes

A

two; all

66
Q

What are the 3 planes that SSC sense movement?

A
  1. Yaw (right / left)- Horizontal rotation
  2. Pitch (front/back)- Flexion /tension (up and down)
  3. Roll/bank (ear up/down/Bank = side to side )- Lateral flexion
67
Q

The 6 individual canals form ____ coplanar pairs

A

three Co-plane together (anterior of one side and posterior of other side are co-planar)

68
Q

What is the “push-pull” rhythm in the co-planar pairing of SCCS?

A

the endolymph of the co-planar pair is displaced in opposite direction with respect to to the ampulla

69
Q

Therefore, within the co-planar pair, increased neural firing on one side will _____ (increase/decrease) neural firing on other side

A

decrease

70
Q

The planes of the canals are closely aligned with the optimal pulling direction of the _______ muscles. What does this allow?

A

extra-ocular

This allows the vestibular ocular reflex (VOR) to be precisely calibrated to direction and velocity of head movement

71
Q

Medial and lateral rectus are directly aligned with the _____ system

A

horizontal

72
Q

What are the 3 advantages co-planar pairing?

A
  1. Provides “sensory redundancy” in the event of unilateral loss
  2. Allows brain to ignore changes in neural firing that occurs on both sides simultaneously (eg. changes due to increase body or environmental temp)
  3. Assists in compensation of sensory overload
73
Q

What happens when there is damage to one side of the vestibular system?

A

(while can get the other side to compensate)

Once turn the other side of = not good enough data

Don’t usually go for the bad side and will turn good side off

74
Q

What is a simple rule to tell the directions that excite each canal?

A

“ a canal is excited by head motion towards that canal, in the appropriate plane”

75
Q

The right horizontal canal is excited by ____ head turns

A

right

76
Q

The right posterior canal is excited by ______ left head tilts

A

right posterior

77
Q

The left anterior canal is excited by ______ head tilts

A

left anterior

78
Q

What direction does the fluid go in ampullopetal?

A

Displacement “toward” the ampulla

79
Q

What direction does the fluid go in ampullopetal?

A

Displacement “away” from the ampulla

80
Q

Head turns will cause excitation of one vestibular nerve and ____ of its paired canal

A

inhibition

81
Q

The vestibular nerve which is being inhibited will drop to a firing rate of 0 (spikes per second) for head velocities at _____ deg/sec (normal daily activities average 120 deg/sec). Therefore, head velocities > 180deg may be unquantifiable by _____ the vestibular system

A

180; half

82
Q

Response to rotations that excite a canal are _____ (greater/less) than response to rotations that inhibit a canal

A

greater

83
Q

Clinically – people with a UVL (unilateral vestibular lesion) often avoid ____ head motion ____ (toward/away) the side of the lesion (inhibitory signal on intact side is not adequate enough at high speeds)

A

rapid; toward

84
Q

What are utricle and saccule?

A
85
Q

Utricle and Saccule are arranged to enable them to respond to motion in all three dimensions in an ____ individual

  • saccule = ____ (vertical/horizontal)
  • utricle = ____ (vertical/horizontal)

Sense orientation of the head with respect to gravity (tilt)

A

upright; vertical; horizontal

86
Q

What are 3 sense linear acceleration of the head?

A
  1. occipito-caudal
  2. antero-post
  3. lateral
87
Q

Sense orientation of the head is with respect to _____ (tilt)

A
88
Q

What are the otolith organs: utricle and saccule?

A
89
Q

What is the vestibular ocular reflex?

A

important mechanism to maintain stable vision during rapid or non-constant head movements

90
Q

What are 3 characteristics of VOR?

A
  1. Head must be moving at variable velocity
  2. Visual target is stationary or in motion
  3. Maintain image of interest steady on the fovea of the retina during head movements
91
Q

What are 2 components of VOR?

A
  1. Angular VOR - compensates for rotation (SCCs)
  2. Linear VOR - compensates for translation (otoliths)
92
Q

What are 4 characteristics for angular VOR?

A
  1. Rotation of the head stimulates SCCs
  2. Triggers an inhibitory signal to the extraocular muscles on one side and an excitatory signal to the muscles on the other side.
  3. The result is a compensatory movement of the eyes.
  4. Eyes opposite to head rotation
93
Q

What are 3 characteristics of VOR?

A
  1. Eyes opposite to linear head movement
  2. Mediated by the otolith organs (Eg. problems with not knowing that they are in a lift)
  3. Most important when near targets are being viewed and the head is being moved
94
Q

What is Ewalds 1st law?

A

Eye and head movement always occur in the same plane of the canal being stimulated and in the direction of the flow of the endolymph

Eye movement being referenced is named by the fast component of nystagmus (the compensatory eye movement to acceleration – the VOR)

95
Q

What is Ewalds 2nd law?

A

Horizontal canal stimulation towards the utricle (cupula towards) produces a greater response than inhibition (cupula moving away from the utricle)

96
Q

What is Ewalds 3rd law?

A

In vertical canals (PSCC & ASCC) reversal of the cupular movement causes stimulation and inhibition within the functional pair of canals.

97
Q

In Ewalds 2nd and 3rd law, asymmetric neural function is accommodated if both _____ of the functional pair are working

A

canals

98
Q

In Ewalds 2nd and 3rd law, asymmetric neural function builds a bias (velocity storage centre) if canals of the functional pair are ______ in their function.

A

asymmetric

99
Q

What are 4 consequences of asymmetry?

A
  1. Dizziness – vertigo, Spinning, giddiness – Nausea / vomiting / Oscillopsia (Unable to see )
  2. Imbalance / falling / ataxic gait
  3. Tilting
  4. Nystagmus (jumping eyes)
100
Q

What is nystagmus?

A

“Jumpy” eyes

Involuntary rhythmic movement of the eye consisting of a slow drift of the eye in one direction, with a corrective quick “jerk” in the opposite direction – Slow drift is the pathological feature

101
Q

What is the result of nystagmus?

A

an imbalance of neural signals arriving at the occulomotor neurons

102
Q

What is nystagmus described as?

A

in reference to the patient and by the direction of the fast component

103
Q

A nystagmus, if there is a torsional component, it is named by what the ____ pole of the eye is doing

A

superior

104
Q

An nystagmus can be ____, _____ or _____ (torsional)

A

horizontal; vertical; rotary

105
Q

What is the gain of VOR?

A

Gain = output /input – i.e. eye movement head movement

106
Q

What does a gain of 1 mean (in VOR)?

A

Eye movement velocity = head movement velocity

Normal Eg. 200/200

107
Q

What does a gain of 0.5 mean (in VOR)?

A

eye movement velocity < than head movement velocity

108
Q

What is classified as abnormal in VOR gain?

A

Anything lower than 1 = abnormal (vestibular loss)

109
Q

Gain is _____ (increased/decreased) with vestibular loss

A

decreased

110
Q

What is the difference between nystagmus and gain or VOR?

A

Nystagmus = there is a loss (don’t know if its from the brain, vestibular system)

Gain of VOR = there is a loss (know that its from the vestibular)

111
Q

What are 3 other oculomotor systems?

A
  1. Smooth pursuit tracking
  2. Saccadic eye movements
  3. Optokinetic system
112
Q

What are 4 characteristics of smooth pursuit tracking?

A
  1. Maintains an object of interest on the fovea with and without head movements
  2. Trajectory of object must be predictable
  3. Pursuit mechanism not sustainable with velocities > 70/s; frequencies >1Hz; accelerations >240/sec
  4. Used instead of the VOR to maintain clear visual viewing from no movement to head movements up to 5 Hz
113
Q

What is a characteristic of saccadic eye movements?

A

Mechanism to replace a target of interest onto the fovea if has moved off

114
Q

What are 3 situations where saccadic eye movements are used?

A
  1. smooth pursuit cannot be used secondary to pathology
  2. outside the normal velocity for pursuit
  3. trajectory is unpredictable
115
Q

What are 4 characteristics of optokinetic system?

A
  1. Maintains visual objects on the fovea when in constant motion – no acceleration so the VOR is not active
  2. Is a combination of both pursuit tracking and saccades – so tracks the object and then resets to the next object or the same one with the head in a new position
  3. With just visual motion can create strong sensation of motion
  4. This system backs up the VOR when the head is not accelerating or decelerating
116
Q

What does the summary of the VOR reflexes

A
117
Q

What is the purpose of the Vestibulospinal reflex (VSR)?

A

stabilise head on the body and maintain upright posture

118
Q

What does the VSR result from?

A

from motor output from vestibular nuclei to spinal motor neurones

119
Q

What is the VSR used for?

A

Uses otolith input to a greater extent than the SCCs - ie related to tilt / gravity rather than rotation

120
Q

What is an example of the VSR?

A

– e.g. standing on a boat rocking side to side, VSR stabilises head by counteracting trunk sway

121
Q

What are the 3 major connects of the VSR?

A
  1. Lateral vestibulospinal tract – antigravity postural motor activity
  2. Medial vestibulospinal tract – ongoing postural changes or head righting in response to SCC
  3. Reticulospinal tract – unclear / probably involved in most balance reflexes
122
Q

What is the function of the vestibulocollic reflex (VCR)?

A

Acts on the neck musculature in order to stabilise the head

123
Q

The VCR has head movement that counter the movement sensed by the ____ or ____ organs

A

otolithic or SCC

124
Q

What are the 3 roles of the vestibular system in postural control?

A

Depends on the nature of the task & on the environmental conditions

Most important when:

  1. stabilisation of the head is critical for good performance
  2. when somatosensory or visual information is not available
  3. when there is conflict between the somatosensory and visual systems

PHTY2230 Prac Exam (Balance and Vestib) (12 decks)

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