Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BMS242 Cell and Molecular S1 > L11 Vesicular Trafficking I > Flashcards

L11 Vesicular Trafficking I Flashcards

1
Q

What types of SNAREs are there

A

v-SNAREs and t-SNAREs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are transport vesicles coated in?

A

Clathrin, COPI & COPII

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is a paradigm for transport vesicle formation

A

COPII coated vesicle

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What associates with the rough ER

A

ribosomes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How are newly made proteins translocated into organelles

A

co-translationally or post-translationally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What does translocation into the ER require

A

signal

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How are membrane proteins inserted into the ER

A

signal peptidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What ensures proper protein folding in the ER

A

chaperones

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What do defects in protein folding give rise to

A

disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What do misfolded proteins stimulate?

A

unfolded protein response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the essential components for all transport vesicle formation

A

GTPase, adaptor proteins, and coat

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What act as molecular switches

A

GTPases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What converts GDP to GTP

A

guanine nucleotide exchange factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What converts GTP to GDP

A

GTPase activating proteins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Where is GDP form usually found

A

cytosol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Where is GTP form usually found

A

membrane

17
Q

What is the main member of GTPases

A

Ras

18
Q

What is the GTPase component of COPII

A

Sar1

19
Q

What is the adaptor component of COPII

A

Sec23/24

20
Q

What is the coat component of COPII

A

Sec13/31

21
Q

Adaptor protein function

A

recognise and select cargo ensuring specificity

22
Q

What do adaptor proteins recognise

A

motifs in cytoplasmic domains

23
Q

AP2

A

major clathrin adaptor

24
Q

What is AP2 involved in

A

endocytosis

25
Q

What do coat proteins provide

A

structural scaffold

26
Q

What experiments allow us to understand what makes a COPII vesicle

A

reconstitution experiments

27
Q

Ribophorin

A

resident ER protein

28
Q

P58

A

COPII cargo protein

29
Q

Where are GTPases recruited from

A

cytosol

30
Q

GTP mutant

A

cannot hydrolyse GTP

31
Q

GDP mutant

A

sequester GEFs

32
Q

Mutant GTPases effect

A

dominant negative

33
Q

Expression of Sar1GDP inhibits

A

COPII formation

34
Q

COPII cargo

A

newly synthesised proteins

35
Q

COPI cargo

A

retrieved & newly synthesised protein

36
Q

Clathrin cargo

A

lysosomal proteins, regulated secretory proteins, endocytosed material

BMS242 Cell and Molecular S1 (13 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions