L11 Respiratory Tract Infections: RSV and PIV Flashcards

1
Q

Croup etiology

A

PIV Type 1 > PIV Type 2/3 > RSV

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2
Q

croup age group

A

6-18 months

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3
Q

croup symptoms

A

fever, hoarseness, barking cough

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4
Q

Croup’s barking cough is due to is due to

A

complication of upper respiratory tract infection that creates tracheal constriction below the vocal cords

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5
Q

Parainfluenza virus (PIV) was

A

originally thought to be the true influenza virus

Is now known to be a paramyxovirus

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6
Q

Paramyxoviruses (3)

A

RSV
Measles
Mumps

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7
Q

Paramyxoviruses

A

Nonsegmented
Negative sense ssRNA genome
Enveloped
4 known serotypes

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8
Q

causes syncytia formation of paramyxoviruses

A

Novel fusion protein (F)

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9
Q

Serotypes of paramyxoviruses

A

hemagluttinin and neuraminidase activites on the same peplomer molecule

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10
Q

PIV life cycle

A

enters respiratory tract

replicates in upper respiratory tract/nasal turbinates ciliated epithelial cells

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11
Q

PIV incubation

A

2-6 days

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12
Q

PIV symptoms

A

harsh cough
rhinitis
sore throat
SOB

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13
Q

PIV may invade lower airways in those at risk:

A

Infants
Young children
Closed poulations
Military recruits

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14
Q

PIV complications

A

otitis media

Parotitis

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15
Q

PIVs that are seasonal

A

Types 1 and 2

fall/winter epidemics, prevalent in children

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16
Q

PIV that isn’t seasonal

A

type 3

endemic, most children have antibody by one year

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17
Q

newly observed PIV

A

type 4

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18
Q

PIV immunity

A

not lifelong, repeat infections with homotypic virus are observed

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19
Q

reservoirs for infant PIV illness

A

Caregivers with minor colds

20
Q

how to diagnose PIV

A

direct viral isolation from throat swab

direct FAB test

21
Q

PIV vaccine

A

ain’t any

22
Q

RSV stands for

A

respiratory syncytical virus

23
Q

RSV season

A

annual winter outbreaks in infants

24
Q

RSV symptoms

A

cough
dyspnea
cyanosis
+/- croup

25
Q

Most common cause of croup

A

PIV 1 and 2

** mentioned like 3 times in the lecture **

26
Q

mental state + RSV

A

may exacerbate dyspnea due to panic

27
Q

symptoms of RSV are due to

A

inflammatory response to infection: IgE, T cells

28
Q

how to diagnose RSV

A

Rapid antigen tests
Nucleic acid tests
Serology- 4x rise (weak)

29
Q

who to screen with a rapid antigen tests

A

all infants with clinical RSV symptoms

30
Q

most common etiology of lower respiratory tract infection in children under 4

A

RSV

31
Q

peak incidence of RSV

A

infants under 1 year

32
Q

highest hospitalization rate from RSV

A

infants 2-3 years

33
Q

increased risks associated with RSV

A

underlying disease

premature birth

34
Q

if you’re born ________, you have the worst chances with RSV

A

3-4 months before RSV season

35
Q

SARS stands for

A

Severe Acute Respiratory Syndrome

36
Q

SARS is a

A

novel coranovirus that emerged in chinal

37
Q

SARS sperad

A

respiratory

fecal-oral

38
Q

SARS has a _______ but is ______

A

high fatality rate

presumed to be extinct

39
Q

MERS stands for

A

Middle East Respiratory Syndrome

40
Q

MERS is a

A

novel coranovirus

41
Q

large outbreak of MERS in

A

South Korea

42
Q

multiple threat agensts, GI and respiratory systems

A

Coronaviruses

43
Q

have zoonotic reservoirs

A

Coronaviruses

44
Q

viruses makes respiratory tract infections common because

A

antibiotics are ineffective

most don’t have vaccines

45
Q

acute illness makes respiratory tract infections common because

A

patients may infect others before showing symptoms

46
Q

many respiratory tract infections are transmitted by _________ which makes them super common

A

healthy carrier reservoirs