L11 Respiratory Tract Infections: RSV and PIV Flashcards
Croup etiology
PIV Type 1 > PIV Type 2/3 > RSV
croup age group
6-18 months
croup symptoms
fever, hoarseness, barking cough
Croup’s barking cough is due to is due to
complication of upper respiratory tract infection that creates tracheal constriction below the vocal cords
Parainfluenza virus (PIV) was
originally thought to be the true influenza virus
Is now known to be a paramyxovirus
Paramyxoviruses (3)
RSV
Measles
Mumps
Paramyxoviruses
Nonsegmented
Negative sense ssRNA genome
Enveloped
4 known serotypes
causes syncytia formation of paramyxoviruses
Novel fusion protein (F)
Serotypes of paramyxoviruses
hemagluttinin and neuraminidase activites on the same peplomer molecule
PIV life cycle
enters respiratory tract
replicates in upper respiratory tract/nasal turbinates ciliated epithelial cells
PIV incubation
2-6 days
PIV symptoms
harsh cough
rhinitis
sore throat
SOB
PIV may invade lower airways in those at risk:
Infants
Young children
Closed poulations
Military recruits
PIV complications
otitis media
Parotitis
PIVs that are seasonal
Types 1 and 2
fall/winter epidemics, prevalent in children
PIV that isn’t seasonal
type 3
endemic, most children have antibody by one year
newly observed PIV
type 4
PIV immunity
not lifelong, repeat infections with homotypic virus are observed