L1 Introduction

Question 1

How chemicals become a therapeutic drug (different phases)

Answer 1

Scientific dev → Clinical dev → Clinical use

Question 2

Understand drug development & utilisation

Answer 2

(Principals) Molecular → Cell & Tissues → Organ → Whole body → Population (Practice)

Question 3

Scientific basis of drug action

Answer 3

• Angel’s trumpet → treat heart failures
  
  • Discovered Ouaban extract → a cardiac glycoside
• May not understand mechanism, but through observation understand it’s helpfulness

Question 4

Examine, synthesise, evaluate knowledge pertaining to drug

Answer 4

• Examine, synthesise & evaluate knowledge pertaining to drug
  
  • Ach only relaxes BV with an intact endothelium
    
    • Endothelial cells release EDRF (NO) → Treats pulmonary hypertension & angina

Question 5

Impact of contemporary thinking in numerous fields of research

Answer 5

• Understand oxidative stress of NO
  
  • Too much O2 → generates free radicals → interacts with NO → cell damage
  • Most diseases have a degree of oxidative stress