L1 and 2 - Autonomic drugs Flashcards
What are the 2 main fibres of neurone?
pre and post ganglionic
what are the 2 main NT?
cholinergic and adrenergic
what 2 systems is the nervous system split into?
- central
2. peripheral
2 branches of peripheral NS
somatic and autonomic
which NS is the sympathetic and parasympathetic a part of ?
autonomic
4 conditions where autonomic drugs are used?
- angina
- asthma
- anaphylactic shock
- hypertension
what does the parasympathetic system do?
rest and digest
what does the sympathetic system do?
fight or flight
where do parasympathetic neurones synapse?
cranial and sacral
where do sympathetic neurones synapse?
thoracic, lumbar, sacral
what type of synapse are ALL pre-ganglionic synapses in the ANS?
Cholinergic
what is the difference between the post-ganglionic synapses in the parasympathetic and sympathetic NS?
para - Ach
symp - ACh and NE
describe the difference in synapses in the symp NS
sweat glands - Ach
Cardiac +smooth muscle, gland cells, nerve terminals - NE
what synapses are the in somatic nervous system?
ACh
2 main types of autonomic receptors?
cholinoceptors
adrenoceptors
2 types of adrenoceptors
alpha and beta
2 types of cholinoceptors
nicotinic and muscarinic
what are the adrenoceptor alpha and beta subtypes?
a-1, a-2
b1 to b3
what are the cholinoceptor nicotinic subtypes?
muscle, ganglion and CNS
what are the cholinoceptor muscarinic subtypes?
M1 to M5
what type of receptors are in the heart for sympathetic stimulation?
B1
what type of receptors are in the heart for parasympathetic stimulation?
M2
which 2 tissues arterioles can both constrict and dialate (para and symp systems)?
erectile tissue and salivary glands
what type of transduction method is there in nicotinic receptors?
type 1 ionitropic