L 14-15

Question 1

Enzymes assoc. with Acetylcholine production/breakdown

Answer 1

Choline acetyltransferase–production

Acetylcholinesterase–breakdown

Question 2

Enzymes assoc. c Catecholamine synth/breakdown

Answer 2

Tyrosine hydroxylase–production
Monoamine Oxidase (MAO)–breakdown

Question 3

Metabolism products of catecholamines

Answer 3

Dopamine–>Homovanillic Acid
Epinephrine–>Metanephrine
Norepinephrine–>Normetanephrine

Epi & NE –>Vanilla Mandelic Acid (VMA)

Question 4

Basics of M1

Answer 4

CNS, Glands

Gq coupled

Question 5

Basics of M2

Answer 5

Heart, S.M., presynaptic

Gi coupled

Question 6

Basics of M3

Answer 6

Primary Muscarinic receptor
Exocrine glands, S.M., Endothelium
Gq coupled

Question 7

Basics of Alpha1

Answer 7

Vasoconstriction (S.M. excitatory)

Gq coupled

Question 8

Basics Alpha2

Answer 8

Presynaptic
Gi coupled
Brain, platelets, S.M.

Question 9

Basics of Beta1

Answer 9

Heart

Gs coupled

Question 10

Basics of Beta2

Answer 10

Heart (minimal)
Lungs (major)
Dilates vessels to muscles including heart
Increases aqueous humor
Gs coupled
Most sensitive to down regulation

Question 11

Basics of Beta3

Answer 11

Lipolysis

Question 12

ANS receptors in Heart

Answer 12

PS: M2-> dec HR, dec Conduction

S: Beta1-> inc HR, inc conduction, inc contractility
Beta2-> small effect, also inc blood flow

Question 13

ANS receptors in Lungs

Answer 13

PS: M3-> bronchoconstriction

S: Beta2-> bronchodilation

Question 14

ANS receptors in Blood Vessels

Answer 14

PS: no innervation, but I.V. Ach has some vasodilation effect

S: Alpha1-> vasoconstriction

Question 15

ANS receptors in Eyes

Answer 15

PS: M3-> Miosis, accomodation, helps evacuate humor

S: Alpha1-> Mydriasis
Beta2-> inc humor

Question 16

ANS receptors in glands

Answer 16

PS: M3-> lacrimation, salivation

S: M1-> sweating
Alpha1-> salivation

Question 17

ANS receptors in GI

Answer 17

PS: M3-> inc motility, inc secretions, relax sphincters

S: Alpha2/Beta2-> relax GI, tighten sphincters
Beta2-> glycogenolysis, INC K+ UPTAKE
Beta3-> lypolysis

Question 18

ANS receptors in GU

Answer 18

PS: M3-> contract bladder, relax sphincters, erection

S: Beta1-> inc renin
Beta2-> relax bladder & uterus
Alpha1-> Ejaculation, tighten sphincters