Kyle Lecture Asthmatic/cardiac Flashcards
Describe ion flow during ventricular action potential
3 Phases of SA node action potential
4-leaky Na channels, slight upslope
0-Na Ca influx
3-K efflux
Primary effect on action potential
Na channels blockade
Slows depolarization of fast AP cells
Primary effect on action potential
Beta blockade
Slows depolarization in slow AP cells
Primary effect on action potential
K channels blockade
Prolongs action potential
Primary effect on action potential
CA channel blockade
Slows depolarization in slow AP cells
Fast AP cells types
Atria, ventricle, HIS/purkinje
Slow AP cells
Sinus and AV nodes
Primary effect on EKG
Na channel block
Widens QRS complex
Primary effect on EKG
Beta blockade
Slows sinus rate and prolongs PR interval
Primary effect on EKG
K channel block
QT prolongation
Primary effect on EKG
Ca channel block
Slows sinus rate and prolongs PR
-same as beta
Differentiate strength of sodium channel blockade and primary impact on action potential
1a- moderate, increases AP -procainamide
1b- weak, decreases AP- lidocaine
1c- strong, no effect on APD but strong right shift on upstroke
Rate control in WPW/afib
Procainamide
Pill in the pocket, outpatient afib conversion
Flecainide