Antiarrhythmic Drug Deck Flashcards
Class 1a
Mechanism and specific drugs
Na channel block
K channel block
Repolarization prolonged
Quinidine
Procainamide
Disopyramide
Class 1a
Clinical use and adverse effects
Ventricular arrhythmias
WPW-procainamide
Maintenance of NSR after afib conversion
QT prolongation- torsades
Lupus like syndrome
Class 1B
Mechanism and specific drugs
Sodium channel block
Repolarization shortened
Lidocaine
Tocainide
Mexiletine
Class 1B
Clinical use and adverse effects
V tach/fib- lidocaine
Atrial fibrillation
Seizure
Tremor
Confusion
1C
Mechanism and specific drugs
Na channel block
No effect on repolarization
Flecainide
Propafenone
1C
Clinical use and adverse effect
Paroxysmal A-fib prevention
Do not use after MI
Proarrhythmic-HF
II
Mechanism and specific drugs
Beta blockade
Non selective vs selective
Non selective beta blockers
Propranolol and nadolol
Propranolol also shows class 1 effects
B1 selective
Esmolol
Metoprolol
Atenolol
Bisoprolol
II
Clinical use and adverse effects
Reduce MI mortality
Rate control
Recurrence of tachyarrhythmias
Bradycardia, hypotension, depression, fatigue
III
Mechanisms and drugs
K channel block
Sotalol- also a beta blocker
Amiodarone/dronedarone- also have 1 & 2 activity
Ibutilide
III
Clinical uses and adverse effects
WPW
Vtach/fib
A flutter/fibrillation conversion
Proarrhythmic-torsades via QTP
Hypotension/bradycardia
N/V
IV
Mechanism and drugs
Calcium channel block
Nifedipine
Nicardipine
Diltiazem
Verapamil
Phenylalkylamine
IV
Clinical uses and adverse effects
Hypertension
Bradycardia
Hypotension
Ankle swelling
