Kruse - Skeletal Muscle Relaxants

Question 1

ending of nondepolarizing neuromuscular blocking drugs - isoquinoline derivatives

Answer 1

-curium, or -curarine

Question 2

ending of nondepolarizing neuromuscular blocking drugs - steroid derivatives

Answer 2

-onium

Question 3

depolarizing neuromuscular agent

Answer 3

succinylcholine

Question 4

spasmolytics (mm relaxants)

Answer 4

dantroline, botulinum toxin

Question 5

antimuscarinic cmpds

Answer 5

atropin, glycopyrrolate

Question 6

cholinesterase reactivators

Answer 6

pralidoxime

Question 7

nAChR antagonists

Answer 7

nondepolarizing neuromuscular blocking drugs

Question 8

ROA for all neuromuscular blocking drugs

Answer 8

parenterally

Question 9

drugs that interact with neuromuscular blocking drugs

Answer 9

inhaled anesthetics and abx (aminoglycosides)

Question 10

nondepolarizing neuromuscular blocking drugs don’t work well in these pts; need to do what?

Answer 10

burn patients, increase dose

Question 11

can cause prolonged paralysis of pt in ICU who has been on steroidal neuromuscular blocking drugs for several days

Answer 11

3-hydrocy meatbolite > longer T1/2 than parent cmpd - seen in steroid derivative nondepol NMJ blocking drugs

Question 12

tx of malignant hyperthermia

Answer 12

dantroline

Question 13

cleaves SNARE complex and blocks the release of ACh by preventing vesicle exocytosis

Answer 13

botulinum toxin

Question 14

tx spacticity ass’d with UMN disorders & malignant hyperthermia

Answer 14

dantroline

Question 15

inhibition of RyR Ca channels to block release of Ca through the sarcoplasmic reticulum to impair mm contraction

Answer 15

Dantroline

Question 16

responsible for the hydrolysis and metabolism of succinylcholine

Answer 16

butyrylcholinesterase

Question 17

AChEi’s that are give by IV and don’t have CNS action

Answer 17

quaternary

Question 18

AChEi’s that can be given IV or oral and penetrate the CNS

Answer 18

tertiary

Question 19

GABAb receptor agonist - used to tx reversible spasticity ass’d with MS or spinal cord lesions

Answer 19

baclofen

Question 20

promotes GABA binding to GABAa receptor > increased inhibition and decreased spasticity - tx anxiety, etoh w/drawal, skeletal mm relaxant, tx convulsions

Answer 20

diazepam

Question 21

alpha2 andronergic agonist > decreases excitatory input into alpha motor neurons to tx mm spasticity

Answer 21

tizanidine

Question 22

antagonizs purine matabolism and may inhibit DNA, RNA, and protein synthesis - immunosupp used to tx RA and renal transplant

Answer 22

azathioprine

Question 23

nonspecific K channel blocker > improves focal conduction of demylinated axons - used to help improve walking in MS pts

Answer 23

dalfampridine

Question 24

given as a monthy bolus to tx primary or secondary progressive MS

Answer 24

glucocorticoids

Question 25

mix of random polymers of 4 AA thats antigenically similar to MBP - used to management of relapsing-remitting type MS

Answer 25

glatiramer acetate

Question 26

intercalates DNA resulting in cross-links and strand breaks - antineoplastic used to tx MS, AML, and advances prostate cancer

Answer 26

mitoxatrone