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MSK II > Kruse - Skeletal Muscle Relaxants > Flashcards

Kruse - Skeletal Muscle Relaxants Flashcards

1
Q

ending of nondepolarizing neuromuscular blocking drugs - isoquinoline derivatives

A

-curium, or -curarine

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2
Q

ending of nondepolarizing neuromuscular blocking drugs - steroid derivatives

A

-onium

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3
Q

depolarizing neuromuscular agent

A

succinylcholine

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4
Q

spasmolytics (mm relaxants)

A

dantroline, botulinum toxin

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5
Q

antimuscarinic cmpds

A

atropin, glycopyrrolate

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6
Q

cholinesterase reactivators

A

pralidoxime

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7
Q

nAChR antagonists

A

nondepolarizing neuromuscular blocking drugs

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8
Q

ROA for all neuromuscular blocking drugs

A

parenterally

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9
Q

drugs that interact with neuromuscular blocking drugs

A

inhaled anesthetics and abx (aminoglycosides)

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10
Q

nondepolarizing neuromuscular blocking drugs don’t work well in these pts; need to do what?

A

burn patients, increase dose

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11
Q

can cause prolonged paralysis of pt in ICU who has been on steroidal neuromuscular blocking drugs for several days

A

3-hydrocy meatbolite > longer T1/2 than parent cmpd - seen in steroid derivative nondepol NMJ blocking drugs

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12
Q

tx of malignant hyperthermia

A

dantroline

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13
Q

cleaves SNARE complex and blocks the release of ACh by preventing vesicle exocytosis

A

botulinum toxin

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14
Q

tx spacticity ass’d with UMN disorders & malignant hyperthermia

A

dantroline

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15
Q

inhibition of RyR Ca channels to block release of Ca through the sarcoplasmic reticulum to impair mm contraction

A

Dantroline

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16
Q

responsible for the hydrolysis and metabolism of succinylcholine

A

butyrylcholinesterase

17
Q

AChEi’s that are give by IV and don’t have CNS action

A

quaternary

18
Q

AChEi’s that can be given IV or oral and penetrate the CNS

A

tertiary

19
Q

GABAb receptor agonist - used to tx reversible spasticity ass’d with MS or spinal cord lesions

A

baclofen

20
Q

promotes GABA binding to GABAa receptor > increased inhibition and decreased spasticity - tx anxiety, etoh w/drawal, skeletal mm relaxant, tx convulsions

A

diazepam

21
Q

alpha2 andronergic agonist > decreases excitatory input into alpha motor neurons to tx mm spasticity

A

tizanidine

22
Q

antagonizs purine matabolism and may inhibit DNA, RNA, and protein synthesis - immunosupp used to tx RA and renal transplant

A

azathioprine

23
Q

nonspecific K channel blocker > improves focal conduction of demylinated axons - used to help improve walking in MS pts

A

dalfampridine

24
Q

given as a monthy bolus to tx primary or secondary progressive MS

A

glucocorticoids

25
Q

mix of random polymers of 4 AA thats antigenically similar to MBP - used to management of relapsing-remitting type MS

A

glatiramer acetate

26
Q

intercalates DNA resulting in cross-links and strand breaks - antineoplastic used to tx MS, AML, and advances prostate cancer

A

mitoxatrone

MSK II (9 decks)

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