Kruse In class lecture and DSA

Question 1

half life and clearance relationship

Answer 1

inversely related

Question 2

pharmacodynamics is

Answer 2

drug target (receptor, enzyme, etc)

Question 3

what is the antidote to warfarin

Answer 3

vitamin K

don’t eat foods high in vitamin K while on warfarin

Question 4

butyrylcholinesterase polymorphism

Answer 4

takes longer for pt to breakdown succinyl choline

-longer for pt to break out of paralytic state

Question 5

grapefruit juice irreversibly inhibits what enzyme

Answer 5

CYP3A4

Question 6

___ containing drugs can cause hemolytic anemia in pts with G6PD deficiency

Answer 6

sulfer

Question 7

ryanodine receptor mutations and malignant hyperthermia

Answer 7

elevation of calcium in sarcoplasm of m leads to m rigidity, elevation of body temp, rhabdomyolysis

Question 8

parallel trial

Answer 8

at least 2 regimens are tested simultaneously but pts are asssigned to only 1 therapy

Question 9

endpoint

Answer 9

measured to assess a drug’s effect (blood pressure is endpoint for testing an antihypertensive agent)

Question 10

surrogate endpoint

Answer 10

outcome of therapy that predicts the real goal of therapy without being that goal

-reduction in tumor size as surrogate for survival

Question 11

caveats in human testing

Answer 11

variable natural history and progression of disease
-crossover design, large pop, time

presence of other diseases and risk factors
-drug use

subject and observer bias