Konorev Into to Pharmacodynamics Flashcards

1
Q

non-covalent bonds from strongest to weakest

A

ionic
hydrogen
hydrophobic
van der waals

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2
Q

dose response curve
x axis =
y axis =
what kind of curve

A
x = drug dose
y = response

-hyperbolic curve

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3
Q

2 phases of dose response curve

A

linear and plateua

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4
Q

dose response curve using log

A

gives sigmoidal curve

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5
Q

what is Emax and what axis

A

maximal effect that can be produced by the drug

on Y axis

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6
Q

what is ED50

A

dose of the drug that produces 50% of its maximal effect

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7
Q

what is the affinity of a drug for receptor

A

how readily and tightly that drug binds to its receptor

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8
Q

KD is what

A

equilibrium dissociation constant

drug concentration at which 50% of drug receptor binding sites are occupied by the drug

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9
Q

the lower the Kd the ___ the affinity of drug for receptor

A

higher

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10
Q

the magnitude of a drug’s effect is proportional to

A

the degree of its interaction with (binding to) a receptor

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11
Q

what is EC50

A

concentration of drug that gives half max response

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12
Q

what factor decides if EC50 = Kd

A

depends on coupling of receptor occupancy and response to a drug

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13
Q

drug selectivity is

A

property of a drug determined by its affinities at various binding sites

-measure by comparing affinites of drug to diff receptors or by comparing ED50 for different effects of drug

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14
Q

intrinsic activity

A

ability of drug to change a receptor fnct and produce physiological response upon its binding to a receptor

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15
Q

agonist do or do not have intrinsic activity?

A

do

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16
Q

do inverse agonist have intrinsic activity

A

yes and it is related to the inhibition of receptor function

17
Q

irreversibly bind to and occlude the agonist site on the receptor by forming covalent bonds

A

irreversible antagonist

18
Q

noncompetitive antagonist and receptor inactivation

A

recereceptor inactivation is not surmountable

19
Q

what are the 2 types of non-competitive antagonists

A

irreversible and allosteric

20
Q

drug potency

A

describes amt of drug required to produce specific pharmacological effect

drugs with higher affinities for a receptor (lower kd) are more potent

21
Q

efficacy

A

describes max pharmacological effect that a drug can produce

related to total number of receptors available to bind drug (Bmax)

higher Bmax = higher efficacy

22
Q

the lower the ED50 the ___ the potency of a drug

A

higher

23
Q

what response is represented by mean value within a population or single subject

A

graded response

24
Q

quantal response

A

all or none, yes or no binary response

-does the response occur or not
in how many

25
Q

non-cumulative quantal dose response curve

A

number or % of individuals responding at a dose of a drug only at that dose

26
Q

cumulative quantal dose response curve

A

number or % of individuals responding at a dose of a drug and at all doses lower than that dose

27
Q

therapeutic index

A

TD50 (median toxic dose)/ED50 (median effective dose)

higher TI = safer the drug

28
Q

therapeutic window

A

range of doses of a drug or of its concentration in a bodily system that provides safe and effective therapy