Konorev Into to Pharmacodynamics

Question 1

non-covalent bonds from strongest to weakest

Answer 1

ionic
hydrogen
hydrophobic
van der waals

Question 2

dose response curve
x axis =
y axis =
what kind of curve

Answer 2

x = drug dose
y = response

-hyperbolic curve

Question 3

2 phases of dose response curve

Answer 3

linear and plateua

Question 4

dose response curve using log

Answer 4

gives sigmoidal curve

Question 5

what is Emax and what axis

Answer 5

maximal effect that can be produced by the drug

on Y axis

Question 6

what is ED50

Answer 6

dose of the drug that produces 50% of its maximal effect

Question 7

what is the affinity of a drug for receptor

Answer 7

how readily and tightly that drug binds to its receptor

Question 8

KD is what

Answer 8

equilibrium dissociation constant

drug concentration at which 50% of drug receptor binding sites are occupied by the drug

Question 9

the lower the Kd the ___ the affinity of drug for receptor

Answer 9

higher

Question 10

the magnitude of a drug’s effect is proportional to

Answer 10

the degree of its interaction with (binding to) a receptor

Question 11

what is EC50

Answer 11

concentration of drug that gives half max response

Question 12

what factor decides if EC50 = Kd

Answer 12

depends on coupling of receptor occupancy and response to a drug

Question 13

drug selectivity is

Answer 13

property of a drug determined by its affinities at various binding sites

-measure by comparing affinites of drug to diff receptors or by comparing ED50 for different effects of drug

Question 14

intrinsic activity

Answer 14

ability of drug to change a receptor fnct and produce physiological response upon its binding to a receptor

Question 15

agonist do or do not have intrinsic activity?

Answer 15

do

Question 16

do inverse agonist have intrinsic activity

Answer 16

yes and it is related to the inhibition of receptor function

Question 17

irreversibly bind to and occlude the agonist site on the receptor by forming covalent bonds

Answer 17

irreversible antagonist

Question 18

noncompetitive antagonist and receptor inactivation

Answer 18

recereceptor inactivation is not surmountable

Question 19

what are the 2 types of non-competitive antagonists

Answer 19

irreversible and allosteric

Question 20

drug potency

Answer 20

describes amt of drug required to produce specific pharmacological effect

drugs with higher affinities for a receptor (lower kd) are more potent

Question 21

efficacy

Answer 21

describes max pharmacological effect that a drug can produce

related to total number of receptors available to bind drug (Bmax)

higher Bmax = higher efficacy

Question 22

the lower the ED50 the ___ the potency of a drug

Answer 22

higher

Question 23

what response is represented by mean value within a population or single subject

Answer 23

graded response

Question 24

quantal response

Answer 24

all or none, yes or no binary response

-does the response occur or not
in how many

Question 25

non-cumulative quantal dose response curve

Answer 25

number or % of individuals responding at a dose of a drug only at that dose

Question 26

cumulative quantal dose response curve

Answer 26

number or % of individuals responding at a dose of a drug and at all doses lower than that dose

Question 27

therapeutic index

Answer 27

TD50 (median toxic dose)/ED50 (median effective dose)

higher TI = safer the drug

Question 28

therapeutic window

Answer 28

range of doses of a drug or of its concentration in a bodily system that provides safe and effective therapy