Kruse - Endocrine Signaling/Drug DSAs Flashcards
hormones that act on G(alpha)i effectors
Alpha-andrenergic, somatostatin
Hormones that act at G(alpha)q,11 effectors
TRH, GnRH
Hormones that act at RTKs IRS-1 to IRS4
Insulin
Hormones that act at JAK tyrosine kinsases
GH, PRL
Hormones that act at effector serine kinase
TGR-beta
Somatostatin analogues
Octreotide, lanreotide
Dopamine agonists
Bromocriptine, cabergoline
Vasopressin receptor agonist
Vasopressin, desmopressin
Vasopressin receptor antagonists
Conivaptin, tolvaptan
AEs: SST analogs
diarrhea, nausea, abd pain, gallbladder sludge, gallstones, cardiac effects, vit b12 def
Growth hormone
Soma tropic
GH antagonist
Pegvisomant
IGF-1 agonist
Mecasermin
Thyroid agents
Levothyroxine, liothyronine, liotrix, thyroid desiccated
Antithyroid agents
Radioactive iodine sodium, methimazole, potassium idolize, propylthiouricil
AEs: vasopressin and desmopressin
HA, nausea, abd cramps, agitation, allergic reactions
Inhibits the thyroid all peroxidase-catalyzed relations and blocks iodide organize cation
Thioamides (PTU, methimazole)
Thioamide that can cause hepatitis
PTU
Most serious complication of thioamides
Agranulocytosis
MC AEs of thioamides
Maculopapular puritic rash, fever, nausea, GI distress
Hormones that activate G(aplpha)s effectors
Beta-andrenergic, LH, FSH, TSH, glucagon, PTH, PtHrP, ACTH, GRHR, CRH
anterior pituitary hormones are negatively regulated by
somatostatin and dopamine
TSH release is regulated by
TRH
LH and FSH release is regulated by
GnRH
ACTH release is regulated by
CRH