Kruse - Endocrine Signaling/Drug DSAs

Question 1

hormones that act on G(alpha)i effectors

Answer 1

Alpha-andrenergic, somatostatin

Question 2

Hormones that act at G(alpha)q,11 effectors

Answer 2

TRH, GnRH

Question 3

Hormones that act at RTKs IRS-1 to IRS4

Answer 3

Insulin

Question 4

Hormones that act at JAK tyrosine kinsases

Answer 4

GH, PRL

Question 5

Hormones that act at effector serine kinase

Answer 5

TGR-beta

Question 6

Somatostatin analogues

Answer 6

Octreotide, lanreotide

Question 7

Dopamine agonists

Answer 7

Bromocriptine, cabergoline

Question 8

Vasopressin receptor agonist

Answer 8

Vasopressin, desmopressin

Question 9

Vasopressin receptor antagonists

Answer 9

Conivaptin, tolvaptan

Question 10

AEs: SST analogs

Answer 10

diarrhea, nausea, abd pain, gallbladder sludge, gallstones, cardiac effects, vit b12 def

Question 11

Growth hormone

Answer 11

Soma tropic

Question 12

GH antagonist

Answer 12

Pegvisomant

Question 13

IGF-1 agonist

Answer 13

Mecasermin

Question 14

Thyroid agents

Answer 14

Levothyroxine, liothyronine, liotrix, thyroid desiccated

Question 15

Antithyroid agents

Answer 15

Radioactive iodine sodium, methimazole, potassium idolize, propylthiouricil

Question 16

AEs: vasopressin and desmopressin

Answer 16

HA, nausea, abd cramps, agitation, allergic reactions

Question 17

Inhibits the thyroid all peroxidase-catalyzed relations and blocks iodide organize cation

Answer 17

Thioamides (PTU, methimazole)

Question 18

Thioamide that can cause hepatitis

Answer 18

PTU

Question 19

Most serious complication of thioamides

Answer 19

Agranulocytosis

Question 20

MC AEs of thioamides

Answer 20

Maculopapular puritic rash, fever, nausea, GI distress

Question 21

Hormones that activate G(aplpha)s effectors

Answer 21

Beta-andrenergic, LH, FSH, TSH, glucagon, PTH, PtHrP, ACTH, GRHR, CRH

Question 22

anterior pituitary hormones are negatively regulated by

Answer 22

somatostatin and dopamine

Question 23

TSH release is regulated by

Answer 23

TRH

Question 24

LH and FSH release is regulated by

Answer 24

GnRH

Question 25

ACTH release is regulated by

Answer 25

CRH

Question 26

GH release is regulated by

Answer 26

GHRH

Question 27

prolactin release is regulated by

Answer 27

VIP, GIP

Question 28

TSH and TRH are inhibited by

Answer 28

thyroxine (T4)

Question 29

FSH and LH are inhibited by

Answer 29

estrogen, progesterone, androgens

Question 30

GH is inhibited by

Answer 30

GH (feedback), IGF-1

Question 31

prolactin is inhibited by

Answer 31

hypothalamus (dopamine)

Question 32

ACTH and CRH are inhibited by

Answer 32

cortisol

Question 33

adult with generalized obesity, reduced mm mass, asthenia, reduced CO are deficient in

Answer 33

GH

Question 34

AEs of adult GH use

Answer 34

peripheral edema, myalgias, arthralgias, carpal tunnel sydrome

Question 35

CI: rhGH

Answer 35

pts with known malignancy

Question 36

inhibits release of GH, glucagon, insulin, gastrin

Answer 36

somatostatin (SST)

Question 37

long acting SST analogues

Answer 37

octerotide, lanreotide

Question 38

approved for the tx of acromegaly

Answer 38

lanreotide

Question 39

tx of hyperprolactinemia

Answer 39

bromocryptine or cabergoline

Question 40

dopamine agonist with longer T1/2

Answer 40

cabergoline

Question 41

AEs: dopamine antagonists

Answer 41

N, HA, hypothension, faigye, psych problems, plum infiltrates

Question 42

lng acting synthetic analogue of vasopressin with minimal V1 receptor activity

Answer 42

desmopressin

Question 43

treatment of choice for pituitary (central) DI

Answer 43

vasopressin and desmopressin

Question 44

preferred treatment of choice for pituitary (central) DI

Answer 44

desmopressin d/t V2 selectivity

Question 45

tx of coagulopathy in hemophilia A and vonWillebrand dz

Answer 45

desmopressin

Question 46

vasopressin antagonist selective for V2 receptors

Answer 46

tolvaptan

Question 47

increases free water erestion without a change in systemic vascular resistance of CHF pts

Answer 47

conivaptan

Question 48

Preparation of choice for thyroid replacement therapy

Answer 48

Le thyroxine - T4

Question 49

Thioamides

Answer 49

Methimazole, propylthiouracil

Question 50

T1/2 and dosing of PTU

Answer 50

1.5 h, 3-4 doses per day

Question 51

T1/2 and dosing of methimazole

Answer 51

6 hours, once daily dosing

Question 52

Thioamide to use in first trimester of pregnancy

Answer 52

PTU

Question 53

Inhibits thyroid all peroxidase-catalyze do reations and blocks iodide oragnification

Answer 53

Thioamides - methimazole and PTU

Question 54

Blocks thyroid gland uptake of iodide by competitively inhibiting iodide transport

Answer 54

Anion inhibitors - ClO4-, TcO4-, SCN-

Question 55

Anion inhibitors

Answer 55

Perchlorate (ClO4-), pertechnetate (TcO4-), thiocyanate (SCN-)

Question 56

Inhibit oragnification and hormone release; decrease size and vascular its of hyperplasic thyroid gland

Answer 56

Iodide so

Question 57

AEs: Iodides

Answer 57

Acneiform rash, swollen salivary glands, mucous membrane ulceration so, conjunctivitis, metallic taste

Question 58

Can cross placenta and cause fetal goiter

Answer 58

Iodide so

Question 59

Isotope used for to of thyrotoxicosis

Answer 59

131I

Question 60

MC beta-blocker used to to s/s of elevated thyroid hormone

Answer 60

Propranolol

Question 61

Used to manage tachy in pts where beta-blockers are CI'ed

Answer 61

Diltiazem

Question 62

4 steps to to thyroid storm

Answer 62

Beta-blockers, potassium Iodide, PTU or methimazole, IV hydrocortisone

Question 63

When thyroid storm to isn't working, other options for lowering circulating levels of T4

Answer 63

Plasmapheresis or peritoneal dialysis