Kruse - Endocrine Signaling/Drug DSAs Flashcards

1
Q

hormones that act on G(alpha)i effectors

A

Alpha-andrenergic, somatostatin

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2
Q

Hormones that act at G(alpha)q,11 effectors

A

TRH, GnRH

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3
Q

Hormones that act at RTKs IRS-1 to IRS4

A

Insulin

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4
Q

Hormones that act at JAK tyrosine kinsases

A

GH, PRL

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5
Q

Hormones that act at effector serine kinase

A

TGR-beta

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6
Q

Somatostatin analogues

A

Octreotide, lanreotide

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7
Q

Dopamine agonists

A

Bromocriptine, cabergoline

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8
Q

Vasopressin receptor agonist

A

Vasopressin, desmopressin

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9
Q

Vasopressin receptor antagonists

A

Conivaptin, tolvaptan

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10
Q

AEs: SST analogs

A

diarrhea, nausea, abd pain, gallbladder sludge, gallstones, cardiac effects, vit b12 def

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11
Q

Growth hormone

A

Soma tropic

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12
Q

GH antagonist

A

Pegvisomant

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13
Q

IGF-1 agonist

A

Mecasermin

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14
Q

Thyroid agents

A

Levothyroxine, liothyronine, liotrix, thyroid desiccated

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15
Q

Antithyroid agents

A

Radioactive iodine sodium, methimazole, potassium idolize, propylthiouricil

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16
Q

AEs: vasopressin and desmopressin

A

HA, nausea, abd cramps, agitation, allergic reactions

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17
Q

Inhibits the thyroid all peroxidase-catalyzed relations and blocks iodide organize cation

A

Thioamides (PTU, methimazole)

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18
Q

Thioamide that can cause hepatitis

A

PTU

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19
Q

Most serious complication of thioamides

A

Agranulocytosis

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20
Q

MC AEs of thioamides

A

Maculopapular puritic rash, fever, nausea, GI distress

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21
Q

Hormones that activate G(aplpha)s effectors

A

Beta-andrenergic, LH, FSH, TSH, glucagon, PTH, PtHrP, ACTH, GRHR, CRH

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22
Q

anterior pituitary hormones are negatively regulated by

A

somatostatin and dopamine

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23
Q

TSH release is regulated by

A

TRH

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24
Q

LH and FSH release is regulated by

A

GnRH

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25
Q

ACTH release is regulated by

A

CRH

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26
Q

GH release is regulated by

A

GHRH

27
Q

prolactin release is regulated by

A

VIP, GIP

28
Q

TSH and TRH are inhibited by

A

thyroxine (T4)

29
Q

FSH and LH are inhibited by

A

estrogen, progesterone, androgens

30
Q

GH is inhibited by

A

GH (feedback), IGF-1

31
Q

prolactin is inhibited by

A

hypothalamus (dopamine)

32
Q

ACTH and CRH are inhibited by

A

cortisol

33
Q

adult with generalized obesity, reduced mm mass, asthenia, reduced CO are deficient in

A

GH

34
Q

AEs of adult GH use

A

peripheral edema, myalgias, arthralgias, carpal tunnel sydrome

35
Q

CI: rhGH

A

pts with known malignancy

36
Q

inhibits release of GH, glucagon, insulin, gastrin

A

somatostatin (SST)

37
Q

long acting SST analogues

A

octerotide, lanreotide

38
Q

approved for the tx of acromegaly

A

lanreotide

39
Q

tx of hyperprolactinemia

A

bromocryptine or cabergoline

40
Q

dopamine agonist with longer T1/2

A

cabergoline

41
Q

AEs: dopamine antagonists

A

N, HA, hypothension, faigye, psych problems, plum infiltrates

42
Q

lng acting synthetic analogue of vasopressin with minimal V1 receptor activity

A

desmopressin

43
Q

treatment of choice for pituitary (central) DI

A

vasopressin and desmopressin

44
Q

preferred treatment of choice for pituitary (central) DI

A

desmopressin d/t V2 selectivity

45
Q

tx of coagulopathy in hemophilia A and vonWillebrand dz

A

desmopressin

46
Q

vasopressin antagonist selective for V2 receptors

A

tolvaptan

47
Q

increases free water erestion without a change in systemic vascular resistance of CHF pts

A

conivaptan

48
Q

Preparation of choice for thyroid replacement therapy

A

Le thyroxine - T4

49
Q

Thioamides

A

Methimazole, propylthiouracil

50
Q

T1/2 and dosing of PTU

A

1.5 h, 3-4 doses per day

51
Q

T1/2 and dosing of methimazole

A

6 hours, once daily dosing

52
Q

Thioamide to use in first trimester of pregnancy

A

PTU

53
Q

Inhibits thyroid all peroxidase-catalyze do reations and blocks iodide oragnification

A

Thioamides - methimazole and PTU

54
Q

Blocks thyroid gland uptake of iodide by competitively inhibiting iodide transport

A

Anion inhibitors - ClO4-, TcO4-, SCN-

55
Q

Anion inhibitors

A

Perchlorate (ClO4-), pertechnetate (TcO4-), thiocyanate (SCN-)

56
Q

Inhibit oragnification and hormone release; decrease size and vascular its of hyperplasic thyroid gland

A

Iodide so

57
Q

AEs: Iodides

A

Acneiform rash, swollen salivary glands, mucous membrane ulceration so, conjunctivitis, metallic taste

58
Q

Can cross placenta and cause fetal goiter

A

Iodide so

59
Q

Isotope used for to of thyrotoxicosis

A

131I

60
Q

MC beta-blocker used to to s/s of elevated thyroid hormone

A

Propranolol

61
Q

Used to manage tachy in pts where beta-blockers are CI’ed

A

Diltiazem

62
Q

4 steps to to thyroid storm

A

Beta-blockers, potassium Iodide, PTU or methimazole, IV hydrocortisone

63
Q

When thyroid storm to isn’t working, other options for lowering circulating levels of T4

A

Plasmapheresis or peritoneal dialysis