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Endocrine II > Konorev - Andrenal Corticosteroid Drugs > Flashcards

Konorev - Andrenal Corticosteroid Drugs Flashcards

1
Q

MOA: aminoglutethimidine

A

blocks conversion of cholesterol to pregnenolone

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2
Q

tx: aminoglutethimidine

A

breast cancer and adrenocortical cancer

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3
Q

AEs: aminoglutethimidine

A

drowsiness, GI upset

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4
Q

MOA: ketoconazole

A

inhibits P450 and reduces synthesis of adrenal and sex hormones

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5
Q

tx: ketoconazole

A

antifungal, cushing’s, prostated ca, suppress hair lossq

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6
Q

AEs: ketoconazole

A

hepatotox, gynecomastia

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7
Q

MOA: metyrapone

A

inhibition of 11-hydoxylation > suppression cortisol and corticosterone

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8
Q

tx: metyrapone

A

cushing’s (esp in pregnant women)

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9
Q

AEs: metyrapone

A

Na + H2O retention, hirsutism, GI upset, dizziness

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10
Q

MOA: mitotane

A

non-selective cytotoxic action on adrenal ctx

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11
Q

tx: mitotane

A

adrenal carcinoma

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12
Q

AEs: mitotane

A

depression, somnolence, GI upset, rashes

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13
Q

MOA: mifepristone

A

stabilizaton of hsp90-GR complex > progesterone receptor antagonist

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14
Q

tx: mifepristone

A

hypercortisolism in endogenous cushing’s, anti-progesterone for intrauterine pregnancy termination

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15
Q

AEs: mifepristone

A

dizziness, GI upset, fatigue

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16
Q

MOA: spironolctone

A

aldosterone receptor agonist

17
Q

tx: spironolctone

A

primary HTN, hirsutism, diuretic

18
Q

AEs: spironolctone

A

hyperK, gynecomastia + impotence, menstrual abn

19
Q

MOA: eplerenone

A

competitive antagonist of aldosterone at minderalcoricoid receptors

20
Q

tx: eplerenone

A

HTN, heart failure

21
Q

AE: eplerenone

A

hyperK

22
Q

mineralocorticoids

A

fludrocortisone

23
Q

short-medium acting glucocorticoids (

A 
hydrocortisone
cortisone
prednisone
prednisolone
methyprednisolone
24
Q

intermediate acting glucocorticoids (12-36h)

A

triamcinolone

25
Q

long acting glucocorticoids (>36h)

A

betamethason

dexamethasone

26
Q

steroid synthesis inhibirots

A

aminoglutethimidine
ketoconazole
metyrapone
mitotane

27
Q

glucocorticoid antagonists

A

mifepristone

28
Q

aldosterone antagonists

A

spirionolactone

eplerenone

Endocrine II (4 decks)

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