Konorev - Drugs Used in Diabetes

Question 1

rapid acting insulins

Answer 1

aspart
lispro
glulisine

Question 2

short acting insulins

Answer 2

regular insulin

Question 3

intermediate acting insulins

Answer 3

NPH

Question 4

long acting insulin

Answer 4

detemir

glargine

Question 5

amylin analog

Answer 5

pramlintide

Question 6

GLP-1 agonists

Answer 6

exenatide

liraglutide

Question 7

DPP4 inhibitors

Answer 7

sitagliptin
linagliptin
saxagliptin
alogliptin

Question 8

1st gen sulfonylureas

Answer 8

chlorpropamide
tolbutamide
tolazamide

Question 9

2nd gen sulfonylureas

Answer 9

glipizide
glyburide
glimepiride

Question 10

meglitinides

Answer 10

nateglinide

repaglinide

Question 11

biguanide

Answer 11

metformin

Question 12

thiazolidinediones

Answer 12

pioglitasone

rosiglitazone

Question 13

SGLT1 inhibitors

Answer 13

canagliflozin
dapagliflozin
empagliflozin

Question 14

alpha-glycosidase inhibitors

Answer 14

acarbose

miglitol

Question 15

basal insulin maintenance, 1-2 injections daily

Answer 15

long acting insulin

Question 16

injected 45 min before meals

Answer 16

short acting insulin

Question 17

taken before meals

Answer 17

rapid acting insulin

Question 18

inidcations for insulin

Answer 18

T1 DM, T2 DM, gestational diabetes, severe hyperK

Question 19

MC complication of insulin therapy

Answer 19

hypoglycemia

Question 20

confusion, bizarre behavior, seizures, coma, tachy, palpitations, sweating, tremor, hunger, nausea

Answer 20

signs of hypoglycemia

Question 21

tx of hypoglycemia

Answer 21

glucose
diazoxide
glucagon

Question 22

clinical uses: glucagon

Answer 22

moderate-severe hypoglycemia
beta-blocker OD
radiology of the bowel

Question 23

tx: amylin analogs

Answer 23

T1 and T2 DM

Question 24

drug interations of amylin analogs

Answer 24

ehances effects of anticholinergic drugs in GI tract

Question 25

AEs: amylin analogs

Answer 25

GI s/s: N/V/D, anorexia, | severe hypoglycemia

Question 26

AEs: long acting GLP-1 agonists

Answer 26

GI s/s, lower risk hypoglycemia, linked to pancreatitis, link to pancreatic and possibly thyroid cancer

Question 27

AEs: DPP4 inhibitors

Answer 27

URIs, nasopharyngitis, acute pancreatitis, hypoglycemia

Question 28

AEs: sulfonylureas

Answer 28

hypoglycemia, wt gain, secondary failure, disulfiram-like effect of etoh flushing, HSN reations

Question 29

AEs: meglitinides

Answer 29

wt gain, secondary failure, hypoglycemia

Question 30

MCly used oral agent to tx T2 DM - first line

Answer 30

metformin

Question 31

AE: metformin

Answer 31

GI complications, decreased B12 abs, lactic acidosis

Question 32

MOA: thiazolidinesiones

Answer 32

increase PPAR-gamma epcression > increase GLUT4 in skeletal mm + adiposites, increase insulin sensitivity, antinflammatory actions

Question 33

AEs: thiazolidinesiones

Answer 33

weight gain, edema, HF exacerbation, increased risk of bladder cancer, osteoporosis, increased TC and LDL-C

Question 34

MOA: SGLT2 inhibitors

Answer 34

inhibition of SGLT2 in proximal tubule to increase glucose excretion in urine

Question 35

MOA: alpha-glycosidase inhibitors

Answer 35

inhibits alpha-glycosidases on the brush border of intestinal epi, lowers postprandial hyperglycemia

Question 36

AEs: alpha-glycosidase inhibitors

Answer 36

malabsorption, flatulence, diarrhea, abd bloating, hypoglycemia possible