Krebs Cycle Flashcards
1
Q
Location of kreb cycle
A
Mitochondria, inner membrane (cristae) + matrix
2
Q
production of acetyl CoA
A
- Pyruvate + CoA + NAD -> acetyl CoA + NADH + C02
- irreversible step
3
Q
catalyst of Acetyl CoA production
A
pyruvate dehydrogenase
4
Q
Features of pyruvate dehydrogenase
A
- 3 enzymes + 5 coenzymes
- inhibition -> acetyl CoA + NADH (feed back)
5
Q
Acetyl CoA + oxaloacetate = + enzyme
A
Citrate
- Citrate synthase
- Co A regenerated
6
Q
Citrate ->
A
Isocitrate
- aconitase
7
Q
Isocitrate ->
A
- alpha ketoglutarate
- Isocitrate dehydrogenase
- C02, NADH
8
Q
Alpha ketoglutarate ->
A
- succinyl CoA
- alpha ketoglutarate dehydrogenase
- CO2 + NADH
9
Q
Succinyl CoA ->
A
- > succinate
- Succinyl CoA
- GTP
10
Q
Succinate ->
A
- Fumarate
Succinate dehydrogenase - only enzyme not in matrix - on membrane
FADH2
11
Q
Fumarate ->
A
- Malate
Fumarase
12
Q
Malate ->
A
- oxaloacetate
malate dehydrogenase - NADH
13
Q
Total products
A
3 CO2 (1 from acetyl CoA)
4 NADH (1 from acetyl CoA)
1 FADH2
1 GTP
14
Q
3 main control points
A
- citrate synthase
- isocitrate dehydrogenase
- alpha ketoglutarate
15
Q
Inhibition Of Citrate synthase
A
- Citrate
- ATP
