glycolysis

Question 1

location

Answer 1

• cytoplasm

Question 2

catabolism

Answer 2

• break down of compound
  -ve delta G
  exergonic
  !oxidation!

Question 3

anabolism

Answer 3

• synthesis of compounds
  +ve delta G
  endergonic
  !reduction!

Question 4

reducing agent used by anabolic pathways

Answer 4

NADPH

Question 5

3 possible products of glycolysis

Answer 5

• pyruvate (aerobic)
• lactate (anaerobic)
• Ribose -5- phosphate

Question 6

disaccharide + bond features

Answer 6

• 2 monosaccharides

glycosidic bond - alpha/beta

Question 7

Glucose requiring organs + GLUT transporter

Answer 7

brain - GLUT 1+3
erythrocytes
retina
real medulla

Question 8

GLUT 2 + GLUT 4 tissue types + features

Answer 8

GLUT 4 = fat + adipose, low Km

GLUT 2 = liver, high Km

Question 9

Glucose -> pyruvate, intermediates

Answer 9

Glucose -> glucose 6 phosphate ->

fructose 6 phosphate -> fructose 1,6-bisphosphate -> Pyruvate

Question 10

Catalyst Glucose -> Glucose 6 phosphate

Answer 10

hexokinase

Question 11

Inhibiters hexokinase

Answer 11

Glucose 6 phosphate

Question 12

Glucose 6 phosphate -> fructose 6 phosphate catalyst

Answer 12

phosphoglucose isomerase

Question 13

catalyst Fructose 6 phosphate -> 1,6 bisphosphate

Answer 13

phosphofructokinase

Question 14

Inhibition of Phosphofructokinase (PFK)

Answer 14

• ATP, H+, Citrate

Question 15

Activation of phosphofructokinase

Answer 15

• AMP

Question 16

Products of glycolysis

Answer 16

2 x pyruvate
4 ATP (-2ATP used)
2 NADH

Question 17

Cell = fully charged

Answer 17

all adenylate in ATP form

Question 18

Cell = fully discharged

Answer 18

all adenylate in AMP form

Question 19

Warburg Effect

Answer 19

• Cancer uses glycolysis to support growth + provide biosynthetic molecules
• Increases glucose demand (weight loss)
• Inefficient
• Lactate produced

Question 20

treatment of Warburg effect

Answer 20

• glycolysis inhibitors

2 deoxy glucose dichloroacetate