Konorev--Adrenergic Drugs

Question 1

Methoxamine

Answer 1

A1>a2»»>B

Question 2

Colonidine

Answer 2

A2>a1»»>B

Question 3

Norepinephrine

Answer 3

A1=a2; b1»»b2

Question 4

Epinephrine

Answer 4

A1=a2; b1=b2

Question 5

Doubutamine

Answer 5

B1>B2»>A

Question 6

ISOPROTERENOL

Answer 6

B1=B2»»>A

Question 7

ALBUTEROL, TERBUTALINE

Answer 7

B2»B1»»A

Question 8

DOPAMINE

Answer 8

D1=D2»B1»A1

Question 9

FENOLDOPAM

Answer 9

D1»D2

Question 10

Inhibits Reuptake of DA and NE at presynaptic neuron (indirect)

Answer 10

Cocaine

Question 11

Inhibitors of MAO (indirect) at presynaptic neuron

Answer 11

Selegilizine (eldepryl)

Phenelzine (Nardil)

Question 12

Reverse NE and DA uptake mechanism and increase their release (indirect) at post synaptic membrane

Answer 12

Amphetamines, methylphenidate, tyramine

Question 13

Releasing agent AND a direct adrenergic receptor agonist (at synapse? )

Answer 13

Epinephrine, ephedrine?

Question 14

Indirect acting adrenergic antagonists

Answer 14

Guanethidine (Ismelin)

Metyrosine

Question 15

Non selective a1 and a2 antagonists

Answer 15

Phenolamine (OraVerse)

Phenoxybenzamine (Dibensyline)

Question 16

Direct acting A1 receptor selective antagonist; suffix?

Answer 16

Prazosin (Minipress)
Terazosin (Hytrin)
Tamsulosin (Flomax)
Doxazosin (Cardura)
Alfuzosin (Uroxatral)
Silodosin (Rapaflo)

Suffix=osin

Question 17

Mixed adrenoceptor antagonists

Answer 17

Lebatalol (Trandate)–both a1 and beta

Carvedilol (Coreg)–both a1 and beta

Question 18

Beta adrenoceptor antagonists (B1 and B2)

Answer 18

Propranolol (Inderal)
Pindolol (Visken)
Nadolol (Corgard)
Penbutolol (Levatol)

Question 19

B1 selective adrenoceptor antagonists

Answer 19

Metoprolol (Toprol)
Betaxolol (Kerlone)
Acebutolol (Sectral)
Atenolol (Tenormin)

Question 20

A1 found where and what are the actions?

Answer 20

Vascular smooth muscle (innervated)–contraction
Pupillary dilator muscle–contraction (dilates pupil)
Pilomotor smooth muscle–erects hair
Prostate–contraction
Heart–increases force of contraction

Question 21

A2 found where and actions?

Answer 21

Postsynaptic CNS neurons
Platelets--aggregation
Adrenergic and cholinergic nerve terminals--inhibits NT release
Some vascular smooth muscle--contraction
Fat cells--inhibits lypolysis

Question 22

B1 found where and actions

Answer 22

Heart, juxtaglomerular cells–increases force and rate of contraction; increases renin release

Question 23

B2 found where and actions

Answer 23

Respiratory, uterine, and vascular smooth muscle–promotes smooth muscle relaxation
Skeletal muscle–promotes potassium uptake
Human liver–activates glycogenolysis

Question 24

B3 found where and actions?

Answer 24

Bladder–relaxes detrusor muscle

Fat cells–activates lipolysis

Question 25

D1 found where and actions?

Answer 25

Smooth muscle--dilates renal blood vessels | Also found in cerebral, mesenteric and coronary vessels

Question 26

D2 found where and actions?

Answer 26

Nerve endings--modulates transmitter release (suppresses NE release)

Question 27

Phenylephrine affinity

Answer 27

A1>A2>>>>>B