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NS2 Test 2 > Konorev--Adrenergic Drugs > Flashcards

Konorev--Adrenergic Drugs Flashcards

1
Q

Methoxamine

A

A1>a2»»>B

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2
Q

Colonidine

A

A2>a1»»>B

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3
Q

Norepinephrine

A

A1=a2; b1»»b2

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4
Q

Epinephrine

A

A1=a2; b1=b2

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5
Q

Doubutamine

A

B1>B2»>A

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6
Q

ISOPROTERENOL

A

B1=B2»»>A

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7
Q

ALBUTEROL, TERBUTALINE

A

B2»B1»»A

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8
Q

DOPAMINE

A

D1=D2»B1»A1

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9
Q

FENOLDOPAM

A

D1»D2

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10
Q

Inhibits Reuptake of DA and NE at presynaptic neuron (indirect)

A

Cocaine

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11
Q

Inhibitors of MAO (indirect) at presynaptic neuron

A

Selegilizine (eldepryl)

Phenelzine (Nardil)

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12
Q

Reverse NE and DA uptake mechanism and increase their release (indirect) at post synaptic membrane

A

Amphetamines, methylphenidate, tyramine

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13
Q

Releasing agent AND a direct adrenergic receptor agonist (at synapse? )

A

Epinephrine, ephedrine?

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14
Q

Indirect acting adrenergic antagonists

A

Guanethidine (Ismelin)

Metyrosine

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15
Q

Non selective a1 and a2 antagonists

A

Phenolamine (OraVerse)

Phenoxybenzamine (Dibensyline)

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16
Q

Direct acting A1 receptor selective antagonist; suffix?

A 
Prazosin (Minipress)
Terazosin (Hytrin)
Tamsulosin (Flomax)
Doxazosin (Cardura)
Alfuzosin (Uroxatral)
Silodosin (Rapaflo)

Suffix=osin

17
Q

Mixed adrenoceptor antagonists

A

Lebatalol (Trandate)–both a1 and beta

Carvedilol (Coreg)–both a1 and beta

18
Q

Beta adrenoceptor antagonists (B1 and B2)

A

Propranolol (Inderal)
Pindolol (Visken)
Nadolol (Corgard)
Penbutolol (Levatol)

19
Q

B1 selective adrenoceptor antagonists

A

Metoprolol (Toprol)
Betaxolol (Kerlone)
Acebutolol (Sectral)
Atenolol (Tenormin)

20
Q

A1 found where and what are the actions?

A

Vascular smooth muscle (innervated)–contraction
Pupillary dilator muscle–contraction (dilates pupil)
Pilomotor smooth muscle–erects hair
Prostate–contraction
Heart–increases force of contraction

21
Q

A2 found where and actions?

A 
Postsynaptic CNS neurons
Platelets--aggregation
Adrenergic and cholinergic nerve terminals--inhibits NT release
Some vascular smooth muscle--contraction
Fat cells--inhibits lypolysis
22
Q

B1 found where and actions

A

Heart, juxtaglomerular cells–increases force and rate of contraction; increases renin release

23
Q

B2 found where and actions

A

Respiratory, uterine, and vascular smooth muscle–promotes smooth muscle relaxation
Skeletal muscle–promotes potassium uptake
Human liver–activates glycogenolysis

24
Q

B3 found where and actions?

A

Bladder–relaxes detrusor muscle

Fat cells–activates lipolysis

25
Q

D1 found where and actions?

A

Smooth muscle–dilates renal blood vessels

Also found in cerebral, mesenteric and coronary vessels

26
Q

D2 found where and actions?

A

Nerve endings–modulates transmitter release (suppresses NE release)

27
Q

Phenylephrine affinity

A

A1>A2»»>B

NS2 Test 2 (16 decks)

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