Knowledge blocks Flashcards
Tyrpsin
Cut right of LYS and ARG
Chymotyrpsin
cut to the right of aormatic amino acids such as PHE, TRY and TRP
Elastase
Cut to the right of the three smallest amino acids GLY, ALA, SER
CNBr
Cut to the right of MET
Aminopeptidase
Curt to the right of the amino terminal of amino acid
Mercaptoethanol
breaks up disulfide bonds
4 effects of ACIDOSIS
GABA increase Denatures protein Hyperkalemia leads to arrhythmias Kussmaul breathing
Organ with the lowest km for any substrate = highest affinity or potency
Brain
5 pathways occur in both compartment
Heme synthesis Gluconeogenesis Urea cycle Fatty acid synthesis Pyrimidine synthesis
Energy Utilization
Plasma (serum) glucose = lasts 2 - 4 hours Liver glycogen = lasts 24- 48 Proteolysis for glconeogenesis = starts at 2 days Lipolysis = begins at end of day 2 ketogenesis
Opiates
CNS depressants
Muscle relaxants
Analgesics
Reducing agent
Negative delta E
Gives away electrons
Oxidized after reaction
Oxidizing agent
Positive delta E
Accepts electrons
Reducued after reaction
XR
G6PD
Fabry’s
Hunter’s
CGD
Adrenoleukodystrophy
ADA
OTC
PRPP synthetase
Tyrosine Kinase
Classes of Neurotransmitters
AA
monoamines
peptides
AA inhibitory neurotransmitters
GABA of the brain
Glycine of the spinal cord
AA excitatory neurotransmitters
Glutamate
Aspartate
Monoamines neurotransmitter
Dopamine
norepinephrine
epinephrine
serotonin
Polypeptides
CCK
Substance P
Neurpeptide
others:
Opioids
endocannabinoids
NO/CO
PEEP
Prevent atelectasis
↑ Oxygenation without increasing the risk of oxygen toxicity
↑ Gas exchange area
↑ Functional residual capacity
↑ Pulmonary compliance
Which values are prevalence dependant
PPV and NPV
AD (17)
Achondroplasia
Autosomal dominant polycystic kidney disease (ADPKD)
Ehler-Danlos syndrome
Familial adenomatous polyposis
Familial hypercholesterolemia
Hereditary spherocytosis
Huntington disease
Li-Fraumeni syndrome
Marfan syndrome
Multiple endocrine neoplasias
Myotonic muscular dystrophy
Neurofibromatosis type 1
Neurofibromatosis type 2
Osler-Weber-Rendu syndrome
Osteogenesis imperfecta
Tuberous sclerosis
Von Hippel-Lindau disease
AR (13)
Oculocutaneous albinism
ARPKD
Cystic fibrosis
Friedreich ataxia
Glycogen storage diseases
Hemochromatosis
Kartagener syndrome
Mucopolysaccharidoses (except Hunter syndrome, which is an X-linked recessive disorder)
Phenylketonuria
Sickle cell anemia
Sphingolipidoses (except Fabry disease, which is an X-linked recessive disorder)
Thalassemias
Wilson disease
XD (4)
Alport syndrome
Fragile X syndrome
Hypophosphatemic rickets
Rett syndrome
