Knowledge blocks

Question 1

Tyrpsin

Answer 1

Cut right of LYS and ARG

Question 2

Chymotyrpsin

Answer 2

cut to the right of aormatic amino acids such as PHE, TRY and TRP

Question 3

Elastase

Answer 3

Cut to the right of the three smallest amino acids GLY, ALA, SER

Question 4

CNBr

Answer 4

Cut to the right of MET

Question 5

Aminopeptidase

Answer 5

Curt to the right of the amino terminal of amino acid

Question 6

Mercaptoethanol

Answer 6

breaks up disulfide bonds

Question 7

4 effects of ACIDOSIS

Answer 7

GABA increase Denatures protein Hyperkalemia leads to arrhythmias Kussmaul breathing

Question 8

Organ with the lowest km for any substrate = highest affinity or potency

Answer 8

Brain

Question 9

5 pathways occur in both compartment

Answer 9

Heme synthesis Gluconeogenesis Urea cycle Fatty acid synthesis Pyrimidine synthesis

Question 10

Energy Utilization

Answer 10

Plasma (serum) glucose = lasts 2 - 4 hours Liver glycogen = lasts 24- 48 Proteolysis for glconeogenesis = starts at 2 days Lipolysis = begins at end of day 2 ketogenesis

Question 11

Opiates

Answer 11

CNS depressants

Muscle relaxants

Analgesics

Question 12

Reducing agent

Answer 12

Negative delta E

Gives away electrons

Oxidized after reaction

Question 13

Oxidizing agent

Answer 13

Positive delta E

Accepts electrons

Reducued after reaction

Question 14

XR

Answer 14

G6PD

Fabry’s

Hunter’s

CGD

Adrenoleukodystrophy

ADA

OTC

PRPP synthetase

Tyrosine Kinase

Question 15

Classes of Neurotransmitters

Answer 15

AA

monoamines

peptides

Question 16

AA inhibitory neurotransmitters

Answer 16

GABA of the brain

Glycine of the spinal cord

Question 17

AA excitatory neurotransmitters

Answer 17

Glutamate

Aspartate

Question 18

Monoamines neurotransmitter

Answer 18

Dopamine

norepinephrine

epinephrine

serotonin

Question 19

Polypeptides

Answer 19

CCK

Substance P

Neurpeptide

others:

Opioids

endocannabinoids

NO/CO

Question 20

PEEP

Answer 20

Prevent atelectasis

↑ Oxygenation without increasing the risk of oxygen toxicity

↑ Gas exchange area

↑ Functional residual capacity

↑ Pulmonary compliance

Question 21

Which values are prevalence dependant

Answer 21

PPV and NPV

Question 22

AD (17)

Answer 22

Achondroplasia

Autosomal dominant polycystic kidney disease (ADPKD)

Ehler-Danlos syndrome

Familial adenomatous polyposis

Familial hypercholesterolemia

Hereditary spherocytosis

Huntington disease

Li-Fraumeni syndrome

Marfan syndrome

Multiple endocrine neoplasias

Myotonic muscular dystrophy

Neurofibromatosis type 1

Neurofibromatosis type 2

Osler-Weber-Rendu syndrome

Osteogenesis imperfecta

Tuberous sclerosis

Von Hippel-Lindau disease

Question 23

AR (13)

Answer 23

Oculocutaneous albinism

ARPKD

Cystic fibrosis

Friedreich ataxia

Glycogen storage diseases

Hemochromatosis

Kartagener syndrome

Mucopolysaccharidoses (except Hunter syndrome, which is an X-linked recessive disorder)

Phenylketonuria

Sickle cell anemia

Sphingolipidoses (except Fabry disease, which is an X-linked recessive disorder)

Thalassemias

Wilson disease

Question 24

XD (4)

Answer 24

Alport syndrome

Fragile X syndrome

Hypophosphatemic rickets

Rett syndrome