Klebsiella pneumoniae Flashcards
Klebsiella pneumoniae Diseases
1_ Pneumonia
2_UTI
3_sepsis
Characteristics Klebsiella pneumoniae
Facultative gram-negative rods with large polysaccharide capsule.
Habitat of Klebsiella pneumoniae
Habitat is the human upper respiratory and enteric tracts.
Transmission of Klebsiella pneumoniae
Organism is transmitted to the lungs by aspiration from upper respiratory tract and by inhalation of respiratory droplets. It is transmitted to the urinary tract by ascending spread of fecal flora.
Laboratory Diagnosis of Klebsiella pneumoniae
1Gram-stained smear and culture.
2 Characteristic mucoid colonies are a consequence of the organism’s abundant polysaccharide capsule.
3_Lactose-fermenting colonies on MacConkey’s agar.
4_Differentiated from Enterobacter and Serratia by biochemical reactions.
Characteristic of colonies in Klebsiella pneumoniae
mucoid colonies are a consequence of the organism’s abundant polysaccharide capsule.
Pathogenesis of Klebsiella pneumoniae
1_Endotoxin causes fever and shock associated with sepsis.
No exotoxin known.
Organism has large capsule, which impedes phagocytosis.
Chronic pulmonary disease predisposes to pneumonia; catheterization predisposes to UTI.
Type of toxin in Klebsiella pneumoniae
1_Endotoxin causes fever and shock associated with sepsis.
2_No exotoxin known.
Virulence factor of Klebsiella pneumoniae
Organism has large capsule, which impedes phagocytosis.
predisposing factor to Klebsiella pneumoniae
1_Chronic pulmonary disease predisposes to pneumonia
2_catheterization predisposes to UTI.
Klebsiella pneumoniae on MacConkey’s agar.
Lactose-fermenting colonies on MacConkey’s agar.
How to differentiated from Enterobacter and Serratia ?
by biochemical reactions.
Treatment of k.pneumoniae
Cephalosporins alone or with aminoglycosides,
Prevention of k.pneumoniae
1_No vaccine or drug is available.
2_Urinary and intravenous catheters should be removed promptly.
Vaccine of k.pneumoniae
No vaccine or drug is available.
