kjhb Flashcards
1
Q
alpha 1 agonists
A
- adrenaline (prolongation of local anaesthetics, anaphylactic reactions)
- NA
- phenylephrine (nasal decongestant)
2
Q
beta 1 agonists
A
- adrenaline
- NA
- isoprenaline
- dobutamine (contraction of heart muscle)
3
Q
alpha antagonists
A
- ergot alkaloids (ergotamine, ergometrine, hydergine)
- phentolamine
- phenoxybenzamine
4
Q
beta antagonists
A
- atenolol
- propranolol
- sotalol
- carvedilol
- labetolol
5
Q
Post-junctional adrenergic synthesis
A
- Metirosine (tyrosine hydroxylase)
- alpha-methyl DOPA (false transmitter)
- carbidopa (decarboxylase enzyme)
- disulfiram (DA-beta-hydroxylase)
6
Q
Post-junctional adrenergic release
A
- clonidine (inhibit NA)
- guanethidine (inhibit NA release)
7
Q
Post-junctional adrenergic uptake
A
- cocaine (uptake 1)
- tricyclic antidepressants e.g. desmethylimipramine (uptake 1)
- beta-oestradiol (uptake 2)
8
Q
Post-junctional adrenergic metabolism
A
- phenelzine (non-selective MAO)
- selegiline (MAO-B)
- entacapone (COMT)
9
Q
Post-junctional adrenergic storage
A
- reserpine
- tetrabenzine
10
Q
Physiological consequences of alpha blockade
A
- fall in BP -> tachycardia, sodium and water retention
- nasal stuffiness
- postural hypotension
- miosis
11
Q
Therapeutic uses of alpha antagonists
A
- hypertension
- phaeochromocytoma
- BPH
12
Q
Therapeutic uses of beta antagonists
A
- angina
- hypertension
- glaucoma
- myocardial infarction
- arrhythmias
- thyrotoxicosis
- CHF
- anxiety
- prophylaxis of migraine
