Kinetics of Elimination

Question 1

Virtually all drugs are eliminated according to _____.

Answer 1

first order kinetics

Question 2

What does first order kinetics mean?

Answer 2

the rate of elimination [mg/hr] is proportional to the concentration of the drug in the plasma [mg/L]

Question 3

In first order kinetics, the ______ [mg/hr] is proportional to the concentration of the drug in the plasma [mg/L].

Answer 3

rate of elimination

Question 4

In first order kinetics, the rate of elimination [mg/hr] is proportional to the _______ [mg/L].

Answer 4

concentration of the drug in the plasma

Question 5

In first order kinetics, if the concentration of the drug is doubled, the rate of elimination is _____.

Answer 5

doubled

Question 6

Hepatic metabolism and renal excretion are _____ processes.

Answer 6

first order

Question 7

______ and ______ are first order processes.

Answer 7

Hepatic metabolism; renal excretion

Question 8

If drug concentration vs time is graphed, the plots generated represent the _____.

Answer 8

plasma concentration (Cp)

Question 9

What is Ke?

Answer 9

rate constant of elimination for the drug

Question 10

For drugs exhibiting _____, steady state can be assumed to exist by 4-5 half-lives.

Answer 10

first-order kinetics

Question 11

For drugs exhibiting first-order kinetics, steady state can be assumed to exist by _____.

Answer 11

4-5 half-lives

Question 12

In first-order kinetics, after a drug is discontinued, it can be assumed that all drug is eliminated after _____.

Answer 12

4-5 half-lives

Question 13

In ______, after a drug is discontinued, it can be assumed that all drug is eliminated after 4-5 half-lives.

Answer 13

first-order kinetics