Kinetics

Question 1

First Order:

Answer 1

Increase in plasma concentration = increase in rate of drug metabolism

Rate of metabolism proportional to drug concentration

Question 2

Zero Order

Answer 2

> plasma drug concentration = no change in rate of drug metabolism
@max capacity

Rate of metabolism independent of drug concentration

Question 3

First Order:

Answer 3

Increase in plasma concentration = increase in rate of drug metabolism

Rate of metabolism proportional to drug concentration

1/2 life constant

Question 4

Zero Order

Answer 4

> plasma drug concentration = no change in rate of drug metabolism
@max capacity (Vmax)

Rate of metabolism independent of drug concentration = constant rate of drug metabolism

Question 5

Zero Order Common Drugs

Answer 5

aspirin
Phenytoin
EtOH

Question 6

half life & drug metabolism

Answer 6

inversely related

Question 7

4 half life drug remaining

Answer 7

93.75% metabolized

Question 8

clearance

Answer 8

Vol of plasma cleared of drug per unit time

vol/time

Question 9

Rate of Elimination =

Answer 9

Rate of Elimination =
CL * [ ]
Unit: mass/time
CL = clearance

Question 10

CL total =

Answer 10

CL renal + CL hepatic + CL lungs

urine, bile, exhaled air

Question 11

SNP

Enyzme level name?

Answer 11

single nucleotide polymorphisms
(Gene level)

Enzymatic Polymorphism

Question 12

[Plasma] = mass of drug absorbed / Vd

What Vd formula?

Answer 12

Vd an attribute of drug

Vd =
amount of drug aborbed into the blood /
Plasma drug concentration

Question 13

How to calculate IV dose to reach desired [plasma]

Answer 13

[plasma] * Vd = IV dose