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Pharm > Gases > Flashcards

Gases Flashcards

1
Q

Enflurane
MAC?
BG Partition coefficient?
VP?

A

1.7 MAC
1.9 BG coefficient
175 VP

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2
Q

Enflurance

CV

A

> HR

«

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3
Q

Enflurane

Resp Effects

A

> > RR
< response to hypercapnia,&raquo_space;PaCO2
No hypoxic drive
< mucociliary fx

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4
Q

Enflurane

Cerebral

A

> > ICP
CSF secretion/resistance to outflow
EEG changes, tonic/clonic seizure

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5
Q

Sevoflurane

CI

A

Malignant Hyperthermia

Severe Kidney Dysfunction

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6
Q

Halothane

CI

A 
Liver Disease
Hypovolemia
Aortic Stenosis
Pheochrom
Malignant Hyperthermia
Liver Dsfx (unexplained after halothane exp)
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7
Q

Desflurane

CI

A

Malignant Hyperthermia

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8
Q

Isoflurane

CI

A

Malignant Hyperthermia

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9
Q

Enflurane

CI

A

Malignant Hyperthermia
Pre-existing kidney disease
Seizure disorder (known/suspected)

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10
Q

N2O

CI

A 
Pulm HTN
 B12 inhibited
1st Trimester 
Air Cavity: 
 air emboli, Pneumo,
  acute intestine obstruction, 
 intracranial air, tympanic grafting
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11
Q

Enflurane

Structure

A

Halogenated

Methyl Ethyl Ether

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12
Q

Isoflurane

Structure

A

Halogenated

Methyl Ethyl Ether

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13
Q

Desflurane

Structure

A

Fluorinated

Methyl Ethyl Ether

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14
Q

Sevoflurane

Structure

A

Fluorinated

Methyl Isopropyl Ether

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15
Q

Halothane

Structure

A

halogenated

alkane derivative

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16
Q

Halothane
MAC?
BG Partition coefficient?
VP?

A

MAC 0.76
BG 2.3
VP 243

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17
Q

N2O
MAC?
BG Partition coefficient?
VP?

A

MAC 104
BG 0.47
VP 38,770

18
Q

Isoflurane
MAC?
BG Partition coefficient?
VP?

A

MAC 1.2
BG 1.4
VP 239

19
Q

Desflurane
MAC?
BG Partition coefficient?
VP?

A

MAC 6
BG 0.42
VP 680

20
Q

Sevoflurane
MAC?
BG Partition coefficient?
VP?

A

MAC 2.05
BG 0.69
VP 157

21
Q

Which 2 agents depress ventilation the most?

A

Desflurane

Enflurane

22
Q

Which agent least depresses ventilation?

A

Halothane

23
Q

Which 2 agents most depress baro reflex

A

Halothane

Sevoflurane

24
Q

What agent most degraded by soda lime?

A

Sevoflurane

Des least degraded

25
Q

Which 3 agents depress cerebral metabolic rate the most?

A

Isoflurane
Desflurane
sevoflurane

26
Q

2 agents that cause most myocardial depression?

A

Enflurane

Halothane

27
Q

Which agent causes greatest > in CBF?

A

Halothane

28
Q

Brain up take of anesthetic depends on 4 factors:

A

1- blood solubility
2- Cardiac Output
3- Alveolar Ventilation
4- Inspired Concentration

29
Q

2 most important factors of > in alveolar pressure for inhalation agent?

A

Inspired concentration

blood solubility

30
Q

Second Gas Effect

A

High concentration of N2O accelerate rate of uptake of simultaneously inhaled volatile agent

31
Q

MAC r/t to potency

A

lower MAC =

higher potency

32
Q

What MAC prevent movement in 95% of patients?

A

1.3 MAC

33
Q

7 things that < MAC ?

A 
Increasing Age
Hypothermia
CNS Depressant
acute EtOH intoxication
A2 agonist
Pregnancy
< excitatory NTs
34
Q

What age is highest MAC associated?

A

infant,
1-6 months

(except for Sevo,
highest 0-30 days -neonates)

35
Q

Metabolism of inhaled anesthetics

A

Halothane 15-20%
Enflurane 2%
Isoflurane 0.2%
Desflurane 0.02%

Sevoflurane 3-5%

36
Q

Which inhaled agent has preservative?

A

Halothane

Thymol

37
Q

What is the upper limit for inhaled agent w/ N20 in OR?

Volatile used alone?

A

N2O 25 ppm
volatile 0.5 ppm

Alone, volatile 2 ppm

38
Q

Two pungent inhaled agents?

A

Desflurane

Isoflurane

39
Q

Which inhaled volatile agent has least drop in BP?

A

Sevoflurane

40
Q

Which 2 inhaled agents < SVR the most?

A

Desflurane

Isoflurane

Pharm (10 decks)

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