Kidneys Yo Flashcards
If silver stain is used:
Means membrano in the answer
Silver stain with spiked BM?
Membranous glomerulonephritis
Silver stain with split BM?
Membranoproliferative Glomerulonephritis
Congo red stains?
Amyloid
Immunofluorescence Immune complexes
Granular patterns
T3 HS
Immunofluorescence just antibodies?
Smooth lines - Goodpasture
If only foot processes affected?
Minimal change dz
Acute post streptococcal GN
Nephritic
AKA acute proliferative GN
Stripper leaves granular G strings behind that they used to cover their humps. You want to see what they have sub epithelium.
Lab: DNBase or Anti-steptolysin O
Strep pharyngitis or impetigo
Granular IgG, subepithelial immune complexes - bumps
Goodpasture
Nephritic
Most progress to RPGN (crescentic)
Hemoptysis
Linear smooth IgG
Rapidly progressive GN
Nephritic
AKA crescentic
Cresent formation in Bowmans space, will crush the glomerulus
IgA nepropathy
Nephritic
After resp or GI inf - mucosa makes IgA to protect
Eat a burger with a french fry (guy MC) and dip in ketchup (bright red blood in urine)
Mesangial deposits of IgA and C3
Assoc: Celiac, HSP
What two substances can estimate GFR?
Inulin or mannitol
Diarrhea - type of fluid? Loss? Tx?
Isotonic
Contraction of EC
Tx: give bolus of NS - isotonic
Posm equation
2 x Na+ + glucose/18 + urea/2.8
Marathon runner - type fluid loss? Compartments?
Contract EC, hypotonic fluid so IC contracts
both get taller
Net filtration equation
(Pc - Pi) - (^c - ^i) \
P = hydrostatic
Pi ^ = Oncotic
Seems like take two big numbers as the c and subtract the two small numbers
Ex of things that are freely filtered?
Electrolytes - Na, K Glucose Creatinine Inulin, mannitol Urea
Glucose transport
Has a transport max
BS 180-200 getting full
BS 340 = all carriers saturated
and will be excreted
Filtered load equation?
GFR x Plasma conc
Which kidney for transplant?
L - longer renal v
Water under the bridge
Ureters go under uterine a or vas deferens
Dirty brown casts
Acute tubular necrosis
-epithelial casts
Red casts
Kidney bleeding
White casts
Kidney infection
Broad, waxy casts
Kidney failed
RCC genetic?
VHL
Weird ass place RCC can show up?
L sided varicocele - L testes drains into the L renal v then to IVC
Wilms tumor AKA?
Nephroblastoma
WAGR syndrome
All on chr 11 W - wilms A - aniridia - Pax 6 G - genital ambiguous R - retardation
Beckwith Wiederman
Knockout WT-2
Increased IGF-2 –> hypoglycemia
Lots of growth - tongue, body - esp one side
Use for Mannitol? MOA?
decrease IOP and ICP
MOA: increases renal tubular fluid osm
2 loop diuretics? big difference?
Furosemide - sulfa
Ethacrynic acid - NO sulfa
MOA of loop?
Inhibit Na/K/Cl in TAL
Stimulate release of PGE – protects mucosa and dilates afferent
__NSAIDS inhibit action of PGE
Loop use? SE?
Acute pulm edema
SE: ototoxicity, hypoK, dehydration, gout
Acetazolamide - class? MOA?
Carbonic anyhdrase inhibitor
MOA: inhibits carbonic anhydrase in PCT = Inc bicard in lumen
Use for Acetazolamide
ACID-a-zolamide - so tx of metabolic alkalosis and acute mtn sickness
Thiazide diuretics MOA?
Inhibit Na/Cl in DCT
Thiazide use?
HTN, CHF, calcium stones, Nephrogenic DI
SE thiazides
HYPER glycemia, lipids, uricemia, calcemia
HYPOkalemia and natremia
3 K+ sparing diuretics?
Spironolactone
Triamterene/Amiloride
