IMMUNO-MO-FO

Question 1

Diffuse Scleroderma Ab?

Answer 1

DNA topiosomerase I

aka Scl 70

Question 2

CREST Ab?

Answer 2

Centromere Abs

Question 3

X linked agammaglobinemia of Bruton

Answer 3

Fine until 6 mo
Recurrent resp inf
Mut in Bruton tyrosine kinase on X chr
= can’t mature B cells = All Ig are decreased
Electrophoresis = no gamma bump
Inc infections with strep, resp, pseudomonas, hemophilus

Question 4

3rd pouch

Answer 4

Inf para, thymus

Question 5

4th pouch

Answer 5

Sup para, C cells

Question 6

What is the weird ass syn assoc with DiGeorge?

Answer 6

22q11 micro deletion of Tbox1 gene

DiGeorges and VCFS

Question 7

DiGeorge syn

Answer 7

No thymus, no parathyroid = no PTH = Dec Ca2+
Heart: tetrology of fallot (2nd MC: Truncus arterioles)
Increased T cell ing = virus, fungal
LN depleted in paracortex

Question 8

SCID

Answer 8

T and B cell def
X linked - mut in common gamma chain of IL-R
AR - def of adenosine deaminase

Question 9

Wiskott Aldrich Syn

Answer 9

English James Bond, wearing a tie, likes to drink whiskey = Inc Ethyl Alcohol –> Dec Mental fxn
TIE - Thrombocytopenia, infections, eczema
Inc IgE, IgA
Dec IgM
Mut in WASP gene - cytoskeleton glycoprotein

Question 10

AIDS encephalitis

Answer 10

Migroglia

Multinucleated giant cells

Question 11

How does HIV attach?

Answer 11

gp120 - to CD4 and M

Question 12

How does HIV fuse and enter?

Answer 12

CCR5 - 1% pop homo deletion = non progressors

CXCR4

Question 13

HIV sensitive test?

Answer 13

ELISA

Question 14

HIV confirmation?

Answer 14

Western blot

Question 15

Drug that blocks CCR5?

Answer 15

Maraviroc
Avir - AIDS
Rocks

Question 16

CD

Answer 16

SMX-TMP - for pneumocysitis

Question 17

CD

Answer 17

Macrolide - toxo and crypto

Question 18

Take a sulfa drug, next day = hemolysis, think?

Answer 18

G6PD
ie. SMX
Dapsone

Question 19

NK cell CD?

Answer 19

CD 16

CD56

Question 20

1st line against virus and tumor?

Answer 20

NK cells

Question 21

T cell signal transduction?

Answer 21

CD3

Question 22

T helper cells

Answer 22

CD4

Regulate immune responses

Question 23

Cytotoxic T cells

Answer 23

CD8

Kill altered or infected cells

Question 24

Naive B cells

Answer 24

BOTH IgM and IgG

before they’ve seen antigen

Question 25

B cell CDs?

Answer 25

CD 19, 20. 21

Question 26

Monocytes? | CD?

Answer 26

Baby M in blood | CD14

Question 27

Tells SC to become lymphoid SC?

Answer 27

IL-7

Question 28

Tells SC to become myeloid SC?

Answer 28

IL-3 | GM-CSF

Question 29

Myeloid SC to become Eos?

Answer 29

IL-5

Question 30

TDT

Answer 30

Inserts random bases at junctions of VDJ for variability | Marker for early stage T and B cell ALL

Question 31

LN Outer cortex: Paracortex: Inner medulla:

Answer 31

B cells - follicles with germinal centers T cells M

Question 32

Antigen?

Answer 32

Antibody generating substance Foreign, chem complex, big Induce specific Ab

Question 33

Epitope

Answer 33

Antigenic determinant of the antigen

Question 34

What causes margination and rolling in acute inflam?

Answer 34

E-selectins

Question 35

What causes tight binding in acute inflam?

Answer 35

Integrins - aka CD 18 | Def = LAD

Question 36

What attracts Neuts?

Answer 36

C5a, IL-8, LTB4

Question 37

What two things opsonize?

Answer 37

IgG, C3b

Question 38

How does s. aureus work around opsonization?

Answer 38

Protein A binds to Fc part of IgG

Question 39

if you have chronic granulomatous dz, what do you get infected with?

Answer 39

Catalase + bacteria - lack H2O2 | You don't have NADPH = Dec ROS

Question 40

What is increased in keloid scar?

Answer 40

TGF-B

Question 41

Induces Th0 to Th1?

Answer 41

IL-12 | IFN-y

Question 42

Induces Th0 to Th2

Answer 42

IL-4

Question 43

Induces Th0 to Th17

Answer 43

IL-17 TGF-B IL-6

Question 44

Tuberculoid leprosy

Answer 44

Th1 response | Little disease

Question 45

Lepromatous leprosy

Answer 45

Th2 - Th2 response and reciprocal inhibition of Th1 | Disfiguring dz

Question 46

1 Ab response?

Answer 46

IgG

Question 47

What induces IgA?

Answer 47

IL-5 | TGF-B

Question 48

What induces IgE?

Answer 48

IL-4

Question 49

What is our defense against extracellular bacteria with polysaccharide capsule?

Answer 49

Plasma cells Need Ab mediated humoral immunity to opsonize 3: s. pneumo, h flu, n. meningitidis

Question 50

What crosses placenta and = neonatal lupus?

Answer 50

IgG will ro ro ro across the placenta | 3rd degree heart block

Question 51

Sjogrens

Answer 51

Assoc RA Marginal zone NHL Schirmers filter paper test

Question 52

Old woman endometrium atrophic, bely seeded?

Answer 52

Papillary serous adenocarcinoma | Pap tumor with projections that float off and seed

Question 53

Lichen simplex chronicus

Answer 53

Leukoplakia Simply chronic scratching thick skin

Question 54

Lichen sclerosis

Answer 54

Leukoplakia | Paper thin

Question 55

Condyloma lata

Answer 55

Secondary syphilis VDRL-FTA Genital warts that are flat

Question 56

Sphingomyelin accumulates

Answer 56

``` Neiman Pick Jew Cherry red spot Neiman picks his nose with his sphingers (chr 11) = gets big organs from eating it Flicks it on zebra ```

Question 57

Melanoma

Answer 57

HMB-45+ | S100+ = neural crest cells

Question 58

Acral lentiginous

Answer 58

Black people - Bob Marley lived in St. Kits on 9 mile island gene: c-kit - tyrosine kinase, chr 9 --> def in p16 Tx: Imatinib

Question 59

Tinib =

Answer 59

tyrosine kinase inhibitor

Question 60

Imatinib tx for?

Answer 60

Melanoma GI stromal tumor (GIST) CML

Question 61

Lentigo maligna

Answer 61

Best melanoma, best P | Old persons face

Question 62

Familial melanoma?

Answer 62

Chr 9 def in p16

Question 63

Tx Hairy cell leukemia

Answer 63

Claduribine

Question 64

Langerhans histiocytosis

Answer 64

M CD1A + S100+ EM: birbeck granules

Question 65

Cholera toxin

Answer 65

Turns on Cl- channel = inc cAMP | Water follows the Cl-

Question 66

Shigella toxin

Answer 66

Bloody D | Sixty S

Question 67

Diptheria toxin

Answer 67

(DI-2)theria - elongation factor 2

Question 68

Tumbling motility

Answer 68

Listeria monocytogenes

Question 69

Listeria toxin?

Answer 69

Actin rockets to get into the next cell | Intracellular

Question 70

Falling leaf motility

Answer 70

Giardia Lambia | Beaver fever - drink the water they shit in

Question 71

Strawberry cervix and corkscrew

Answer 71

Trichimonas vaginalis | Its tricky to screw a vagina and get a strawberry

Question 72

CF

Answer 72

C7TR C - cAMP Cl- channel 7 - chr 7 70% have deletion phenylalanine at 508 = misfiled and gets tagged w ubuiquitin

Question 73

Two Tx of CF:

Answer 73

Lumacaftor - chaperones misfolded protein to surface | Ivacaftor - opens the gate