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Boards > IMMUNO-MO-FO > Flashcards

IMMUNO-MO-FO Flashcards

1
Q

Diffuse Scleroderma Ab?

A

DNA topiosomerase I

aka Scl 70

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2
Q

CREST Ab?

A

Centromere Abs

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3
Q

X linked agammaglobinemia of Bruton

A

Fine until 6 mo
Recurrent resp inf
Mut in Bruton tyrosine kinase on X chr
= can’t mature B cells = All Ig are decreased
Electrophoresis = no gamma bump
Inc infections with strep, resp, pseudomonas, hemophilus

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4
Q

3rd pouch

A

Inf para, thymus

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5
Q

4th pouch

A

Sup para, C cells

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6
Q

What is the weird ass syn assoc with DiGeorge?

A

22q11 micro deletion of Tbox1 gene

DiGeorges and VCFS

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7
Q

DiGeorge syn

A

No thymus, no parathyroid = no PTH = Dec Ca2+
Heart: tetrology of fallot (2nd MC: Truncus arterioles)
Increased T cell ing = virus, fungal
LN depleted in paracortex

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8
Q

SCID

A

T and B cell def
X linked - mut in common gamma chain of IL-R
AR - def of adenosine deaminase

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9
Q

Wiskott Aldrich Syn

A

English James Bond, wearing a tie, likes to drink whiskey = Inc Ethyl Alcohol –> Dec Mental fxn
TIE - Thrombocytopenia, infections, eczema
Inc IgE, IgA
Dec IgM
Mut in WASP gene - cytoskeleton glycoprotein

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10
Q

AIDS encephalitis

A

Migroglia

Multinucleated giant cells

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11
Q

How does HIV attach?

A

gp120 - to CD4 and M

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12
Q

How does HIV fuse and enter?

A

CCR5 - 1% pop homo deletion = non progressors

CXCR4

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13
Q

HIV sensitive test?

A

ELISA

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14
Q

HIV confirmation?

A

Western blot

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15
Q

Drug that blocks CCR5?

A

Maraviroc
Avir - AIDS
Rocks

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16
Q

CD

A

SMX-TMP - for pneumocysitis

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17
Q

CD

A

Macrolide - toxo and crypto

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18
Q

Take a sulfa drug, next day = hemolysis, think?

A

G6PD
ie. SMX
Dapsone

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19
Q

NK cell CD?

A

CD 16

CD56

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20
Q

1st line against virus and tumor?

A

NK cells

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21
Q

T cell signal transduction?

A

CD3

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22
Q

T helper cells

A

CD4

Regulate immune responses

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23
Q

Cytotoxic T cells

A

CD8

Kill altered or infected cells

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24
Q

Naive B cells

A

BOTH IgM and IgG

before they’ve seen antigen

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25
Q

B cell CDs?

A

CD 19, 20. 21

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26
Q

Monocytes?

CD?

A

Baby M in blood

CD14

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27
Q

Tells SC to become lymphoid SC?

A

IL-7

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28
Q

Tells SC to become myeloid SC?

A

IL-3

GM-CSF

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29
Q

Myeloid SC to become Eos?

A

IL-5

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30
Q

TDT

A

Inserts random bases at junctions of VDJ for variability

Marker for early stage T and B cell ALL

31
Q

LN
Outer cortex:
Paracortex:
Inner medulla:

A

B cells - follicles with germinal centers
T cells
M

32
Q

Antigen?

A

Antibody generating substance
Foreign, chem complex, big
Induce specific Ab

33
Q

Epitope

A

Antigenic determinant of the antigen

34
Q

What causes margination and rolling in acute inflam?

A

E-selectins

35
Q

What causes tight binding in acute inflam?

A

Integrins - aka CD 18

Def = LAD

36
Q

What attracts Neuts?

A

C5a, IL-8, LTB4

37
Q

What two things opsonize?

A

IgG, C3b

38
Q

How does s. aureus work around opsonization?

A

Protein A binds to Fc part of IgG

39
Q

if you have chronic granulomatous dz, what do you get infected with?

A

Catalase + bacteria - lack H2O2

You don’t have NADPH = Dec ROS

40
Q

What is increased in keloid scar?

A

TGF-B

41
Q

Induces Th0 to Th1?

A

IL-12

IFN-y

42
Q

Induces Th0 to Th2

A

IL-4

43
Q

Induces Th0 to Th17

A

IL-17
TGF-B
IL-6

44
Q

Tuberculoid leprosy

A

Th1 response

Little disease

45
Q

Lepromatous leprosy

A

Th2 - Th2 response and reciprocal inhibition of Th1

Disfiguring dz

46
Q

1 Ab response?

A

IgG

47
Q

What induces IgA?

A

IL-5

TGF-B

48
Q

What induces IgE?

A

IL-4

49
Q

What is our defense against extracellular bacteria with polysaccharide capsule?

A

Plasma cells
Need Ab mediated humoral immunity to opsonize
3: s. pneumo, h flu, n. meningitidis

50
Q

What crosses placenta and = neonatal lupus?

A

IgG will ro ro ro across the placenta

3rd degree heart block

51
Q

Sjogrens

A

Assoc RA
Marginal zone NHL
Schirmers filter paper test

52
Q

Old woman endometrium atrophic, bely seeded?

A

Papillary serous adenocarcinoma

Pap tumor with projections that float off and seed

53
Q

Lichen simplex chronicus

A

Leukoplakia
Simply chronic scratching
thick skin

54
Q

Lichen sclerosis

A

Leukoplakia

Paper thin

55
Q

Condyloma lata

A

Secondary syphilis
VDRL-FTA
Genital warts that are flat

56
Q

Sphingomyelin accumulates

A 
Neiman Pick
Jew
Cherry red spot
Neiman picks his nose with his sphingers (chr 11) = gets big organs from eating it
Flicks it on zebra
57
Q

Melanoma

A

HMB-45+

S100+ = neural crest cells

58
Q

Acral lentiginous

A

Black people - Bob Marley lived in St. Kits on 9 mile island
gene: c-kit - tyrosine kinase, chr 9 –> def in p16
Tx: Imatinib

59
Q

Tinib =

A

tyrosine kinase inhibitor

60
Q

Imatinib tx for?

A

Melanoma
GI stromal tumor (GIST)
CML

61
Q

Lentigo maligna

A

Best melanoma, best P

Old persons face

62
Q

Familial melanoma?

A

Chr 9 def in p16

63
Q

Tx Hairy cell leukemia

A

Claduribine

64
Q

Langerhans histiocytosis

A

M
CD1A +
S100+
EM: birbeck granules

65
Q

Cholera toxin

A

Turns on Cl- channel = inc cAMP

Water follows the Cl-

66
Q

Shigella toxin

A

Bloody D

Sixty S

67
Q

Diptheria toxin

A

(DI-2)theria - elongation factor 2

68
Q

Tumbling motility

A

Listeria monocytogenes

69
Q

Listeria toxin?

A

Actin rockets to get into the next cell

Intracellular

70
Q

Falling leaf motility

A

Giardia Lambia

Beaver fever - drink the water they shit in

71
Q

Strawberry cervix and corkscrew

A

Trichimonas vaginalis

Its tricky to screw a vagina and get a strawberry

72
Q

CF

A

C7TR
C - cAMP Cl- channel
7 - chr 7
70% have deletion phenylalanine at 508 = misfiled and gets tagged w ubuiquitin

73
Q

Two Tx of CF:

A

Lumacaftor - chaperones misfolded protein to surface

Ivacaftor - opens the gate

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