Kidney Transplantation Flashcards
1
Q
Types of transplant
A
- living
- deceased (after cardiac death, after brain death)
- pre-emptive
- after starting dialysis
2
Q
What transplant gives the best outcomes?
A
young living donor premptive
3
Q
Compatibility issues
A
- blood group
- tissue type
4
Q
HLA
A
CLASS 1 = HLA-A, HLA-B, present on cells constitutively
CLASS 2 = HLA-DR, present on APC/B cells and activated/injured other cells
- inherit 1 set of alleles from each parent and closeness of match improves results
5
Q
HLA sensitising events
A
- pregnancy
- blood transfusion
- previous transplant
6
Q
Drugs for transplants
A
- steroids
- azathioprine
- MMF
- Cyclosporin
- tacrolimus
- rapamycin
7
Q
Infections
A
Viral = CMV/wart Bacterial = urine/resp Fungal = pneumocystis
8
Q
Other complications
A
- CV disease/IHD/bp increase
- diabetes
- bone
- GI
- cosmetic
- tumours = solid organ, skin, PTLD
