Kidney Transplant

Question 1

Commonly used immunosuppressive regimen

Answer 1

Antimetabolites (azathioprine, MMF)

Steroids

Calcineurin inhibitors (tacrolimus, cyclosporine)

Question 2

Calcineurin inhibitors (cyclosporine and tacrolimus) have afferent arteriolar vasoconstrictor effect

Answer 2

True

Question 3

Initial treatment of first rejection episode

Answer 3

Methylprednisone 500-1000 mg OD for 3 days

Failure to repsond—> antithymocyte globulin

Question 4

Duration of prophylaxis for pcp and cmv infection post transplant

Answer 4

6-12 months

Question 5

Treatment of cmv

Answer 5

Valganciclovir

Question 6

Common malignant lesions in KT patients on immunosuppressive therapy

Answer 6

Cancer of the skin lips
Carcinoma in situ of the cervix
Lymphomas (NHL)

Question 7

Opportunistic infections in renal transplant patients

Peritransplant < 1 month

Answer 7

Wound infections
Herpesvirus
Oral candidiasis
UTI

Question 8

Opportunistic infections in renal transplant patients

Early 1-6 month

Answer 8

CMV 
PCP 
Legionella
Listeria 
Hep B 
Hep C

Question 9

Opportunistic infections in renal transplant patients

Late > 6months

Answer 9

Aspergillus
Nocardia
BK virus
Herpes zoster
Hep B 
Hep C