Glomerular Diseases

Question 1

Sustained proteinuria

Answer 1

> 1-2 g/24hrs

Question 2

Type of proteinuria in most glomerular diseases in adults

Answer 2

Nonselective

Question 3

Type of proteinuria in children with MINIMAL CHANGE disease

Answer 3

Selective, composed mainly of albumin

Question 4

Proteinuria 1-2gm/d
Hematuria with rbc cast 
Pyuria 
Hypertension
Fluid retention 
Rise in crea with dec in glomerular function

Answer 4

Nephritic syndrome

Question 5

Rapid rise in crea in nephritic syndrome

The clinical equivalent of the crescentic GN

Answer 5

RPGN

Question 6

RPGN + lung hemorrhage

Answer 6

Pulmonary - renal syndrome

Question 7

Proteinuria >3.0 g/d
Hypertension
Hypercholesterolemia
Hypoalbuminemia 
Edema/anasarca
Microscopic hematuria

Answer 7

Nephrotic syndrome

Question 8

ANCA-positive

Pauci-immune glomerulonephritis

Answer 8

Granulomatous polyangiitis
Microscopic polyangiitis
Churg-Strauss syndrome

Question 9

Tram tracking

Answer 9

Type I membranoproliferative GN

Question 10

No obvious glomerular lesion by LM negative for deposits by IF
Effacement of foot processes by Em

Answer 10

Minimal change (nil) disease

Question 11

Adequate renal biopsy sample

Answer 11

At least 10, ideally 20 glomeruli

Question 12

Descriptions of renal biopsy specimen

Answer 12

Diffuse >50% of glomeruli
Focal < 50%

Segmental
Global

Question 13

Most common Nephrotic sydrome in elderly
30% in adults
Uniform thickening of basement membrane by LM
Diffuse granular deposits of IgG and C3
Highest reported incidence of renal vein thrombosis, pulmonary embo, DVT

Answer 13

Membranous GN