Kidney Pathophysiology Flashcards
What shape are the kidneys? Where are the kidneys located? What is the kidney’s primary function?
Bean shaped
Back of the abdominal wall
Filter blood and removes wastes
What are the two waste products removed by the kidneys?
Uric acid and creatinine
What is one of the kidneys’ functions related to fluid and ion levels?
Balance electrolyte levels in plasma
How does blood enter the kidneys? How does blood exit the kidneys?
Via renal artery
Via renal vein
Name an electrolyte whose levels are balanced by the kidneys?
Sodium
How do the kidneys regulate blood pH?
Regulating loss of H+ and bicarbonate
What percentage of cardiac output goes to the kidney?
25%
What do the kidneys control and retain?
Blood pressure and valuable compounds
Name a hormone released by the kidneys.
What valuable compound do the kidneys retain?
Erythropoietin
Glucose
What is gluco-neogenesis?
Glucose generation pathway
How do the kidneys regulate blood volume? How do kidneys regulate RBC production?
Renin restricts water volume in urine
Releasing erythropoietin that stimulates reproduction
What stimulates the haemocytoblasts?
Erythropoietin
What empties into the ureter? What are the papillae made of? What makes up most of the medulla of the kidney?
Pelvis
Apices of 2 or more pyramids
The pyramids
What is the functional unit of the kidney? How many are there in total? What happens to the number after age 40?
Nephron
~1 million
Decreases by 10% every 10 years
Name a part of the main structure of a nephron. What is the function of the Renal corpuscle? List the parts of the renal corpuscle.
Bowman’s capsule
Filter
Bowman’s capsule and Glomerulus
List the different types of tubules in the nephron. Name two types of nephrons
PCT, DCT, Loop of Henle
Juxtamedullary and cortical nephrons
What do cortical nephrons lack?
Vasa recta
What is the function of the Afferent arteriole? What process occurs in the afferent arteriole? What is the function of the efferent arteriole?
Takes blood into glomerulus tubules
Ultrafiltration of blood under pressure
Takes blood out to capillaries
What are the two capillary types connected to the efferent arteriole? What arteriole brings blood into Bowman’s capsule? What arteriole takes blood away from Bowman’s capsule?
Peritubular capillaries and vasa recta
Afferent
Efferent
What is the function of the glomerulus?
Filtration of blood plasma
What are the three layers of the glomerular filtration barrier? What type of cells are in the Glomerular Filtration Barrier?
Cells, Basement Membranes, Podocytes
Capillary endothelial cells
What are the tubules made of? What supports the tubules?
Narrow, single celled layer
Basement membrane
How many segments do the tubules have? What are these segments?
8
Proximal convoluted, proximal straight, descending LoH (thin), ascending LoH (thin), ascending LoH (thick), distal convoluted, cortical collecting duct, medullary collecting duct
What three processes account for renal excretion? How is the urinary excretion rate calculated?
Filtration, Secretion, Reabsorption
Filtration - re-absorption + secretion