ECG and Arrhythmias Flashcards

1
Q

What is the approximate normal heart rate in beats per minute (BPM)?

A

~70bpm

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2
Q

What heart rate in BPM is classified as Bradycardia? What heart rate in BPM is classified as Tachycardia?

A

<60bpm
>100bpm

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3
Q

Which part of the heart is the APEX? What is the native pacemaker of the heart?

A

Bottom tip
SA node

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4
Q

What is the typical BPM range of the SA node?

A

60-100bpm

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5
Q

What is another name for latent pacemakers? What term describes pacemakers other than the SA node?

A

Ectopic pacemakers
Latent pacemakers

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6
Q

What is the typical BPM range of the AV node? What is the typical BPM range of the Bundle of His? What is the typical BPM range of the Purkinje fibers?

A

50-60bpm
50-60bpm
30-40bpm

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7
Q

Through which heart structure does the cardiac impulse spread rapidly? Where is the cardiac impulse delayed in the heart’s conduction pathway?

A

Atria
AV node

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8
Q

How long is the delay at the AV node? Via which fibers does the cardiac impulse spread rapidly to the ventricles?

A

0.1s
Purkinje fibres

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9
Q

To which surfaces of the ventricles do Purkinje fibers transmit the cardiac impulse? Does the cardiac impulse spread more or less rapidly epicardially?

A

Endocardial surfaces
Less rapidly

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10
Q

How many milliseconds does it take for the cardiac impulse to go from the SA node to the AV node? How many milliseconds does it take for the cardiac impulse to travel through the Bundle of His? How many milliseconds does it take for the cardiac impulse to travel through the Purkinje fibres?

A

30ms
130ms
30-40ms

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11
Q

Which system controls heart rate?

A

Autonomic NS

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12
Q

Which branch of the autonomic nervous system has vagal activity? What are the 2 branches of the autonomic nervous system that control heart rate?

A

Parasympathetic
Parasympathetic and sympathetic

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13
Q

What happens during phase 4 depolarisation?

A

K+ efflux
Ca2+ influx
If influx
Deactivation of K+ channels

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14
Q

How many leads does a typical ECG have?

A

12

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15
Q

How many chest leads does a 12 lead ECG have? How many limb leads does a 12 lead ECG have?

A

6
6

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16
Q

What is the normal range of the QRS complex?

A

120-200ms

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17
Q

What can an elevated ST segment on an ECG indicate?

A

MI

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18
Q

On an ECG, which of these equations describes diastole? On an ECG, which interval represents systole?

A

RR-QT
QT interval

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19
Q

How can heart rate be calculated from an ECG?

A

(n-1/△ t)* 60
n = number of r waves
△t = time between them

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20
Q

What is a common type of ECG trace used for quick heart rhythm assessment?

A

Rhythm strip

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21
Q

Name the three types of leads used in ECGs?

A

Chest, augmented, bipolar limb

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22
Q

How is cardiac arrhythmia generally defined in relation to normal sinus rhythm?

A

Any change

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23
Q

What are the causes of arrhythmias?

A
  1. Increased sinus node automaticity
  2. Decreased sinus node automaticity
  3. Escape rhythms
  4. Enhanced automaticity of latent pacemakers (ectopic beats/rhythms)
  5. Triggered activity (after depolarisations): hypokaleamia, drug toxicity
  6. Conduction abnormalities/block
  7. Unidirectional block and re-entry
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24
Q

What is a typical BPM range for sinus tachycardia? What drives sinus tachycardia?

A

100-180
Sinus node

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25
What changes in autonomic tone can cause sinus tachycardia?
Decreased vagal and increased sympathetic
26
When sinus tachycardia is observed, what is the recommended approach?
Treat the cause
27
What heart rate defines sinus bradycardia? When can sinus bradycardia be considered normal?
<60bpm During sleep or a fit athlete
28
What cardiac event can lead to sinus bradycardia due to interrupted blood supply to the SA node? What electrolyte imbalance can induce sinus bradycardia?
Following MI Hyperkalaemia
29
What thyroid condition can induce sinus bradycardia? Can the body tolerate sinus bradycardia?
Hypothyroidism As low as 45bpm
30
What is the general approach to treating sinus bradycardia?
Treat underlying condition Stop medication
31
What ECG characteristic defines sinus arrest? Which ECG complex is missing in sinus arrest?
Missing beats PQRST complex
32
What is the difference between a sinus pause and a sinus arrest in terms of missing beats?
Pause is 1-2, arrest is 3+
33
What is the primary characteristic of sick sinus syndrome? How does heart rate respond to exercise in individuals with sick sinus syndrome?
Slow resting heart rate Does not increase
34
What causes can lead to sick sinus syndrome?
Drug induced Intense vagal activity Degeneration of the pacemaker
35
Is sinus arrhythmia considered a normal phenomenon?
Yes
36
How can sick sinus syndrome be treated?
Artificial pacemaker
37
What happens to heart rate during inspiration in sinus arrhythmia? In what age groups is sinus arrhythmia typically more pronounced?
Accelerates Children and young adults
38
What happens to heart rate during expiration in sinus arrhythmia? What fluctuations cause sinus arrhythmia?
Slows down Vagal activity
39
How much can normal heart beats vary due to fluctuations in vagal activity?
o.5-3%
40
What type of altered balance can lead to inactivation of INa or ICa? What type of injury can lead to inactivation of INa or ICa?
Ionic currents Injured tissue
41
How excitable is depolarized tissue? How does the conduction spread in depolarized tissue?
Less excitable Slowly
42
What can a completely inexcitable tissue cause?
Complete conduction block
43
What abnormality can bypass the AV node?
Aberrant conduction pathway
44
What does bypassing the AV node normally impose? What can a second conduction pathway predispose? Which syndrome involves a bypass of the AV node?
Conduction delay Supraventricular arrythmias Wolff-Parkinson-White
45
Which interval is shortened in Wolff-Parkinson-White syndrome? Which complex is widened in Wolff-Parkinson-White syndrome?
PR interval QRS complex
46
What is affected by first degree AV block?
AV node conduction
47
What two processes are required for re-entry?
Unidirectional block and slowed conduction
48
What is the ratio of P waves to QRS complexes in first degree AV block? What is the PR interval like in first degree AV block? What is the normal range for the PR interval?
1:1 Unusually long 120-200ms
49
Is first degree AV block usually a serious condition requiring treatment? When might first-degree AV block be observed in young people? What autonomic tone can cause first-degree AV block?
Benign During sleep High vagal
50
What happens to the PR interval until the AV node fails in second degree AV block? In 2nd degree AV block is atrial rhythm regular? In 2nd degree AV block, what happens to ventricular depolarisation every Nth cycle? What symptoms can be associated with second-degree AV block?
Lengthens Yes Is missing Dizziness, syncope
51
In bundle branch blocks, where does the ventricular conduction system fail? How does depolarization occur in bundle branch blocks?
His-Purkinje fibre system Slow depolarisation
52
What does bundle branch block do to the QRS complex? What effect does bundle branch block have on contraction?
Wide QRS complex Slow contraction loss
53
What lung disease can cause right BBB? Right BBB occurs in conditions such as blood clots to the what?
Chronic lung disease Lung
54
What ECG characteristic is associated with atrial flutter? What does it mean if atrial flutter II is transient?
Saw-tooth appearance Comes and goes
55
What symptom is least likely to occur when atrial flutter is less than 100 BPM? What are symptoms of faster rates of atrial flutter?
Asymptomatic Palpitations, dyspnea, weakness
56
What is a potential risk associated with atrial flutter?
Atrial thromboembolism
57
What are treatments for atrial flutter?
Electrical cardioversion Pacemaker Pharmacological therapy Catheter ablation
58
What atrial rate characterizes atrial fibrillation? Why is the ventricular rhythm irregular in atrial fibrillation? What is observed about P waves in an ECG of a patient with atrial fibrillation?
350-600 discharges per minute Only some impulses reach ventricles Discrete P waves not discernable
59
What causes atrial fibrillation? What is a typical ventricular rate in untreated atrial fibrillation?
Wandering re-entrant circuits 140-160 BPM
60
What are causes of atrial fibrillation?
Enlarged atria Heart failure Hypertension CAD Thyrotoxicosis Alcohol
61
Why is a rapid ventricular rate dangerous in atrial fibrillation? What is a dangerous consequence of blood stasis in atrial fibrillation?
It reduces cardiac output Thrombus/emboli
62
What are two classifications of ventricular tachycardia? What underlying conditions are associated with ventricular tachycardia?
Sustained or non-sustained Structural heart disease, MI, heart failure
63
What are treatments for atrial fibrillation?
Antiarrhythmic drugs Electrical cardioversion Catheter ablation Maze procedure
64
What is the appearance of QRS complexes in ventricular tachycardia? What is the typical rate in ventricular tachycardia? What causes polymorphic ventricular tachycardia? What causes monomorphic ventricular tachycardia?
Wide 100-200bpm Delayed repolarisation long QT Re-entrant circuit in ventricle
65
What symptoms can occur in ventricular tachycardia? Why is ventricular tachycardia dangerous?
Syncope, pulmonary oedema, cardiac arrest Can deteriorate into VF
66
What are treatments for ventricular tachycardia?
Electrical cardioversion IV antiarrhythmic drugs
67
What term describes a type of VT with identical QRS complexes?
Monomorphic VT
68
What is the major consequence of ventricular fibrillation? What is the likely outcome if ventricular fibrillation is not quickly reversed? What occurs to the ventricles during ventricular fibrillation?
Loss of cardiac output Death Quiver but do not contract
69
What are causes of ventricular fibrillation?
Heart disease (major cause of mortality in MI) Low K+ Electric shock Some drugs
70
What device might survivors of ventricular fibrillation receive?
ICD (implantable cardioverter defibrillator)
71
What are treatments for ventricular fibrillation?
Prompt electrical defibrillation IV antiarrhythmic drug to prevent recurrence
72
How does the lead of an ICD differ from that of a pacemaker?
Larger, to allow a larger shock
73
What is the primary characteristic of congenital long-QT syndromes? What causes long QT syndromes? What type of channel is often affected in Long-QT syndromes?
Prolonged ventricular repolarisation Different mutations K+
74
What symptoms are associated with Long-QT syndromes? What dangerous arrhythmia can Long-QT syndrome lead to?
Can be asymptomatic Ventricular arrhythmias
75
What does SADS stand for?
Sudden arrhythmic death syndrome
76
For Long-QT syndrome type 1 (LQT1), what is the associated gene, protein, and mechanism?
Gene: KCNQ1 Protein: KvLQT1 (α subunit of Iks K+ channel) Mechanism: Decreased K+ current
77
What inheritance pattern is associated with LQT1? What inheritance pattern is associated with LQT2?
AD and AR AD
78
For Long-QT syndrome type 2 (LQT2), what is the associated gene, protein, and mechanism?
Gene: KCNH2 Protein: HERG (α subunit of IKr) Mechanism: Decreased K+ current
79
For Long-QT syndrome type 3 (LQT3), what is the associated gene, protein, and mechanism? What inheritance pattern is associated with LQT3?
Gene: SCN5A Protein: NAV 1.5 Mechanism: Increased Na+ current AD
80
For Long-QT syndrome type 4 (LQT4), what is the associated gene, protein, and mechanism? What inheritance pattern is associated with LQT4?
Gene: ANK2 Protein: Ankyrin-B (structural protein) Mechanism: Not clear AD
81
For Long-QT syndrome type 5 (LQT5), what is the associated gene, protein, and mechanism? What inheritance pattern is associated with LQT5?
Gene: KCNE1 Protein: minK (β subunit of IKS) Mechanism: Decreased K+ Current AD and AR
82
For Long-QT syndrome type 6 (LQT6), what is the associated gene, protein, and mechanism? What inheritance pattern is associated with LQT6?
Gene: KCNE2 Protein: MiRP1 (β subunit of IKR) Mechanism: Decreased K+ Current AD
83
For Long-QT syndrome type 7 (LQT7), what is the associated gene, protein, and mechanism? What inheritance pattern is associated with LQT7?
Gene: KCNJ2 Protein: IK1 (inward rectifier channel) Mechanism: Decreased K+ Current AD
84
What happens during Phase 0 of the cardiac action potential (ventricular myocyte)? What causes the short repolarization in Phase 1 of the cardiac action potential? What characterises Phase 2 of the cardiac action potential? What happens during Phase 3 of the cardiac action potential?
Rapid depolarisation (Na+ influx) K+ efflux Delay in repolarisation (Ca2+ entry) Rapid repolarisation (K+ efflux)
85
What is the duration of the cardiac action potential?
100-250ms
86
What is the main event in Phase 4 of the cardiac action potential?
Automaticity (slow depolarisation)
87
What current is responsible for the pacemaker potential in the SA node? What must the pacemaker potential reach to trigger an action potential?
If slow Na+ current Threshold
88
What period occurs directly before the relative refractory period? What is another name for the relative refractory period? What period occurs directly after the relative refractory period?
Absolute refractory period Vulnerable period Supranormal period
89
What are the major modes of action for anti-arrhythmic drugs?
Decrease slope of phase 4 (slow rate) Increase threshold potential (slow phase 0) Increase refractory period (lengthen action potential)
90
How does prolonging the refractory period help to prevent arrhythmias? How does impairing conduction help prevent arrhythmias?
Impulse dies out Impulse dies out before re-entry
91
What is the overall aim of anti-arrhythmic drugs? What is the most widely used classification system for anti-arrhythmic drugs?
Prevent re-entrant circuits (loops) Vaughan-Williams classification
92
What are the four classes of anti-arrhythmic drugs in the Vaughan-Williams classification?
Class I: sodium channel blockade Class II: catecholamine blockade Class III: lengthening of refractoriness Class IV: calcium channel blockade
93
What effect do Class 1 antiarrhythmics have on conduction? What effect do Class 1 antiarrhythmics have on sodium channels? In what type of tissue do Class 1 antiarrhythmics slow conduction the most? What other type of channel can Class 1 antiarrhythmics block? What ECG change can Class 1 antiarrhythmics cause?
Slow conduction Restrict rapid inflow of Na+ Damaged tissue K+ channels PR prolonged
94
What effect do class 1b antiarrhythmics like lidocaine have on premature beats? What effect do class 1c antiarrhythmics have on excitability? What type of rhythms are class 1c antiarrhythmics used to suppress?
Supresses premature beats General reduction in excitability Re-entrant rhythms
95
What causes ventricular dysrhythmias following MI?
Increased symp activation
96
How do beta-blockers affect the AV node refractory period? What is the effect of beta-blockers on delayed afterdepolarizations?
Increase Reduce delayed afterdepolarisations
97
When are Class II antiarrhythmics useful? What other action do class II antiarrhythmics possess?
Tachyarrhythmias driven by overactive sympathetic system Membrane stabilising action
98
What effect does amiodarone have on cardiac action potential duration? What effect does amiodarone have on ectopic activity? In what type of tachycardias is amiodarone useful?
Prolongs cardiac action potential Suppresses Re-entrant tachycardias
99
What channels does amiodarone block? What change can amiodarone cause on an ECG? Where is amiodarone extensively bound? What is the elimination half life of amiodarone?
K+ channels Prolongs QT, widens QRS Tissue 10-100 days
100
How is amiodarone typically administered initially? What are some adverse effects of amiodarone?
- As a loading dose Photosensitive rash Thyroid abnormalities Pulmonary fibrosis Corneal deposits
101
Besides being a Class III antiarrhythmic, what other action does Sotalol possess? What effect does Sotalol have on the slow outward K+ current?
Non-selective B-adrenoceptor blocker Delays slow outward K+ current
102
How does sotalol compare to amiodarone in effectiveness and adverse effects?
Less effective but has less adverse effects
103
What dangerous type of ventricular tachycardia can Class III drugs produce? What type of drugs should be avoided while taking class III drugs?
Polymorphic ventricular tachycardia (torsades de pointes) Drugs that lengthen QT interval