Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Organ Systems- Renal > Kidney in systemic disease > Flashcards

Kidney in systemic disease Flashcards

1
Q

C-ANCA =

A

Diffuse cytoplasmic reactivity due to antibodies directed against proteinase-3.

Granulomatosis with polyangitis ( Wegners )

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

P-ANCA

A

Perinuclear reactivity only due to lysosomal myeloperoxidase. May be positive in up to 30% of patients

Microscopic polyangitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Can Pauci-immune glomerulonephritis be ANCA-negative ?

A

Yes it can be ANCA negative and without extra-renal disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What do ANCA’s do ?

A

They are pathogenic and cause endothelial cell injury in glomeruli and blood vessels. They bind to neutrophils causing PNM activation and increased contact adhesion with endothelial cells and vascular structures.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What does Wegners cause ?

A

Rapidly progressive crecentric glomerulonephritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How can you distinguish TMP from DIC ?

A

DIC will have an consumptive coagulopathy with prolonged tests of bleeding.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What do TMP and DIC have in common ?

A

Thrombocytopenia and microangiopathic hemolytic anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

The sudden onset of irritability, lethargy, weakness, pallor, and Oliguria, in a small child 5-10 days following gastroenteritis will suggest what ?

A

Hemolytic Uremic Syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is HUS a triad of ?

A
  1. Microangiopathic Hemolytic Anemia
  2. Thrombocytopenia
  3. AKI
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is HUS a normal complication of ?

A

Gastroenteriris caused by E.Coli

-Shinga Toxin in circulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What does minor endothelial injury do to patients with HUS ?

A

Uncontrolled activation of the complement system with intravascular thrombosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What does thrombotis thrombocytopenic purpura consist of ?

5 things

A
  1. Microangiopathic hemolytic anemia
  2. Thrombocytopenia
  3. Neurologic Dysfunction
  4. Renal Dysfunction
  5. Fever
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What deficiency causes TTP ?

A

ADAMST13

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

If you find microangiopathic hemolytic anemia and thrombocytopenia in a patient with no other explanation for them besides TPP what should you do ?

A

Immediate plasmaphresis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What does Lupus cause ?

A

Immune complex mediatede glomerulonephritis that responds well to immunosupressive drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is vasculitis ?

A

Inflammation of blood vessels, usually autoimmune

17
Q

What is polyarteritis nodosa ?

A

Autoimmune ANCA-negative medium vessel arteritis

18
Q

What are ANCA’s ?

A

They are antibodies against proteinse 3 or myeloperoxidase associated with specific autoimmune disease

19
Q

What is microscopic polyangitis ?

A

Autoimmune nectotizing granulomatous vasculitis of the respiratory tract causing crescentric glomerulonephritis associated with P-anca

20
Q

What is granulomatosis with polyangiitis ?

A

Wegners- autoimmune necrotizing granulomatosus vasculitis of respiratory tract and cause of crescentic glomerulonephritis associates with C-ANCA

21
Q

Hemolytic Uremic Syndrome ?

A

Thrombotic microangiopathy of glomeruli in small children due to Shinga toxin from diarrheal E-Coli H7: 0157 infection

22
Q

Thrombotic Thrombocytopenic Purpura

A

Thrombotic microangiopathy due to VWF multimers from ADAMS13 deficiency

23
Q

What is Lupus Nephritis ?

A

Immune Complex-Mediated Glomerulonephritis of systemic lupus erythematosus

24
Q

What is Scleroderma ?

A

Rapidly progressive renal failure of systemic sclerosis

25
Q

What are the two mechanisms in which vascular diseases can affect the kidney ?

A
  1. Inflammation of the blood vessels

2. Loss of thromboresistance

26
Q

What is an example of medium vessel disease and what is the pathogenesis ?

A

Medium vessel disease (Polyarterious nodosa) will cause renal infarcts and distal glomerular ischemia associated with a decline in GFR not associated with Glomerular inflammation with RBC casts ( usually ANCA - )

27
Q

What are some small vessel diseases and what is their pathogesis ?

A

( Microscopic polyangietis, wegners, and chrug strauss syndrome ) –> they cause focal necrotizing lesions with crescent formation with active urinary sediment
**Endothelial cells are the primary target in small vessel vasculitis

28
Q

What is pauci-Immune Glomerulonephritis ?

A

Refers to the negative immunofluorescence studies usualli in the setting of crescentic glomerulonpphritis

29
Q

What is the pathogenesis of endothelial cell injury by ANCA’s ?

A

PMN activation by ANCA
Inhibition of PR3 inactivation by ANCA
EC activation /lysis by ANCA

30
Q

What kind of disease is Wegners ?

A

Sinopulmonary renal syndrome

31
Q

What are the characteristic aspects of Wegners ?

A
  1. Multinucleated Giant Cells
  2. Vascular Necrosis and thrombosis
    3.

Organ Systems- Renal (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions