Keywords Flashcards
cytoskeleton
responsible for shape and movement. made of microfilaments, intermediate filaments, and microtubules.
ectoderm
embryonic germ layer. makes the nervous system and epidermis.
microfilaments
made of actin and regulate cell shape
mesoderm
embryonic germ layer, forms muscle and connective tissue
intermediate filaments
attach organelles to each other and the membrane. formed of vimentin and cytokeratin
endoderm
embryonic germ layer. forms gut and and internal organs.
vimentin
intermediate filaments that are found in the fibroblasts
neuroectoderm
what the nervous tissue devlops from
cytokeratin
intermediate filaments that are found in the epithelium
occluding
a tight junction that prevents the passage of substances and maintains polarity
cilia
actively move with a 9+2 structure
connexins
what a gap junction is made from, assemble into connexons
parenchyma
performs the main function
adherens junction
attaches cells to eachother and to the cytoskeleton. zonula is made from actin and desomosomes are intermediate filaments
stroma
supports cells
gap junction
coordinates cell activity and communication between adjacent cells
cytology
whole cells can be veiwed if obtained in suspension
fixatives
chemically stabilise tissue
microtome
used to cut tissue samples
haemotoxylin
a stain that colours acidic cell components purple/blue
eosin
a stain that colours basic cell components pink
cryostat
used to cut frozen tissue samples
xylene
used to dewax tissue samples
epidemiology
the study of the distribution and determinates of diease in populations
evidence-based medicine
using the current and best medicine in the treatments of a patient
health
complete state of physical, mental and social wellbeing
alpha helix
right hand helix conformation, twisting of amino acid chain
beta pleat
beta pleated chains can be arranged anti-parrallely or parrallely.
steric repulsion
the arrangement of atoms in a molecule
domains
a conserved part of a given protein sequence and tertiary structure that can evolve, function, and exist independently of the rest of the protein chain
methionine
starts all proteints but rarely present in the final structure.
peptide bond
double bond character as electrons are delocalised over the whole bond, between amino acids
chromatin
complex of chromosomal DNA and RNA. stable structure
heterochromatin
condensed chromatin, genes that are not switched on
nucleosome
2 loops of DNA wrapped around a cluster of 8 histones, where chromatin is packed
histones
rich in basic amino acids. they are important in compacting dna
constitutive
heterochromatin where then gens are not switched on
faculative
heterochromatin where the genes are not switched on, but can be
cyclins and CDKs
regulates and coordinates entry into the cell cycle
oogenesis
meiosis in the ovaries
spermogenesis
meiosis in the testes
karyotype
sum of all chromosomesin the nucleus arranged in homologous paris and by order of size
lepotene
chromatin condenses into chromosomes and the chronotomers are visible
zygotene
bivalent tissue forms and synapsids develop
pachytene
crossing over occurs through formation of chiasmata
dipoltene
chromatids are held together by chiasmata and centromeres
diakenisis
terminalisation occur
terminalisation
the movement of transverse bonds between paired chromosomes in meiosis from their points of origin toward the ends of the chromosomes
purines
A+G, 9 linkage, two rings
pyrimidines
T, C + U, 1 linkage, one ring
phosphodiester bond
bonds between amino acids, double bond structure due to delocalisation of electrons
watson-crick base pairing
A+T/U, C+G
semi-conservative replication
one parental strand is conserved and used as a template.
HDP
helix destabilising protein, stops strands reconnecting during DNA replication
okazaki fragments
formed on the lagging strand
UTR
untranslated region, carries info that affects translation
polymerase
fills gaps between okazaki fragments
hypertrophy
cells increase in size
hyperplasia
cells increase in number
atrophy
cells decrease in size
involution
the number of cells decrease
metaplasia
change in the differention of a cell
neoplasia
permanent alteration of cell growth pattern
necrosis
cell death, ATP processes fail, cell membrane is damaged and cell content leaks out. causes inflammation
apoptosis
programmed cell death
proliferation
cell replication