Key associations Flashcards
Actinic (solar) Keratosis
Precursor to squamous cell carninoma
Acute gastric ulcer associate with CNS injury
Cushing ulcer (increased intracranial pressure stimulates vagal gastric secretion)
Acute gastric ulcer associated with severe burns
Curling ulcer (greatly reduced plasma volume results in sloughing of gastric mucosa)
Alternating areas of transmural inflammation and normal colon
Skip lesions (Chron disease)
Aneurysm, dissecting
Hypertension
Aortic aneurysm, abdominal and descenting aorta
Atherosclerosis
Aortic aneurysm, arch
Tertiary syphilis (syphilitic aortitis), vasa vasorum destruction
Arotic aneurysm, ascending
Marfan syndrome (idiopathic cystic medical degeneration)
Atrophy of the mammillary bodies
Wernicke encephalopathy (thiamine deficiency causing ataxia, opthalmoplegia, and confusion)
Autosplenectomy (fibrosis and shrinkage)
Sickle cell anemia (hemoglobin S)
Bacteria associate with gastritis, peptic ulcer disease, and stomach cancer
H. pylori
Bacterial meningitis (adults and elderly)
Strep Penumonia
Bacterial meningitis (mewborns and kids)
Group B Strep/E. coli (newborns),
Strep Pneumoniae/Neisseria meningitidis (kids)
Benign melaoncytic nevus
Spitz nevus (most common in 1st two decades)
Bleeding disorder with GpIb deficiency
Bernard-Soulier syndrome - defect in platelet adhesion to von Willebrand factor
Brain tumor adults
“MGM Studios” - Metastatic, > Glioblastoma Multiforme, > Meningioma, > Schwannoma.
- All Supratentorial
Brain tumor kids
“Animal Kingdom, Magic Kingdom, Epcot” - Astrocytoma, Meduloblastoma, Ependymoma. - Infratentorial
- Craniophryngioma - supratentorial
Breast Cancer
Infiltrating ductal carcinoma
Breast Mass
Fibrocystic change, carcinoma (in postmenopausal women)
Breast tumor (benign)
Fibroadenoma
Cardiac Primary Tumor
Metastasis Primary myxoma (4:1 left to right atrium; ball and valve)
Cerebellar tonsillar herniation
Chiari II formation
Chronic arrhythmia
Atrial Fibrillation (associated with high risk of emboli)
Chronic atrophic gastritis (autoimmune)
Predisposition to gastric carcinoma (can also cause pernicious anemia)
Clear cell adenocarcinoma of the vagina
DES exposure in utero
Compression fracture
Osteoporosis (type I: postmenopausal woman ; type II: elderly man or woman)
Congenital adrenal hyperplasia, hypotension
21-hydroxylase deficiency
Congenital cardiac anomaly
VSD
Congenital conjugated hyperbilirubinemia (black liver)
Dubin Johnson syndrome (inability of hepatocytes to secrete conjugated bilirubin into bile)
Constrictive pericarditis
TB (developing world); SLE (developed world)
Coronary artery involved in thrombosis
LAD > RCA > LCA
Cretinism
Iodine deficit/hypothyroidism
Cushing Syndrome
- Iatrogenic Cushing (from corticosteroid therapy)
- Adrenocortical adenoma (secretes excess cortisol)
- ACTH-secreting pituitary adenoma
- Paraneoplastic Cushing (due to ACTH secretion by tumors)
Cyanosis (early, less common)
“T’s”
- Tetrology of Fallot
- Transposition of the Great Vessels
- Truncus arteriosus
Cyanosis (late, more common)
VSD, ASD, PDA
Death in CML
Blast crisis
Death in SLE
Lupus Nephropathy
Dementia
Alzheimer disease, multiple infarcts
Demylinating disease in young women
multiple sclerosis
DIC
Severe sepsis, obstetric complications, cancer, burns, trauma, major surgery
Dietary deficit
Iron
Diverticulum in pharnyx
Zenker diverticulum (diagnosed by barium swallow)
Ejection click
Aortic/pulmonary stenosis
Esophageal cancer
Squamous cell carcinoma (worldwide)
Adenocarcinoma (US)
Food poisoning
S. Aureus or B. Cereus
Glomerulonephritis (adults)
Berger disease (IgA nephropathy)
Gynecologic malignancy
Endometrial carcinoma (most common in US) Cervical carcinoma (Most common worldwide)
Heart murmur, congenital
Mitral valve prolapse
Heart valve in bacterial endocarditis
Mitral > aortic (rheumatic fever), tricuspid (IV drug abuse)
Helminth infection (US)
Enterobius vermicularis, Ascaris lumbricoides
Hematoma - epidural
Rupture of the middle meningial aretery (trauma; lentiform shaped)
Hematoma - subdural
Rupture of the bridging veins (crescent shaped)
Hemochromatosis
Multiple blood transfusions or hereditary HFE mutation (can result in CHF, “bronze diabetes,” and increase risk of hepatocellular carcinoma)
Hepatocellular carcinoma
cirrhotic liver (associated with hepatitis B and C and with alcoholism)
Hereditary bleeding disorder
von Willebrand disease
Hereditary harmless jaundice
Gilbert syndrome (benign congenital unconjugated hyperbilirubinemia)
HLA-B27
Ankylosing spondylitis, reactive arthritis, ulcerative colitis, psoriatic arthritis
HLA-DR3 or -DR4
Diabetes mellitus type I, rheumatoid arthritis, SLE
Holosystolic Murmur
VSD, tricuspid regurgitation, mitral regurgitation
Hypercoagulability, endothelial damage, blood loss
Virchow triad (results in venous thrombosis)
Hypertension, secondary
Renal Disease
Hypoparathyroidism
accidental excision during thyroidectomy
Hypopituitarism
Pituitary adenoma (usually benign tumor)
Infection secondary to blood transfusion
Hepatitis C
Infections in chronic granulomatous disease
Staphylococcus aureus, E. coli, Aspergillus (catalase +)
Intellecutal disability
Down Syndrome, fragile X syndrome
Kidney stones
- Calcium = radiopaque
- Struvite (ammonium) = radiopaque (formed by urease + organisms such as Proteus vulgaris or Staphlococcus
- Uric acid = radiolucent
Late cyanotic shunt (uncorrected left to right becomes right to left)
Eisenmenger syndrome (caused by VSD, ASD, PDA; results in pulmonary hypertension/polycythemia)
Liver disease
Alcoholic cirrhosis
Lysosomal storage disease
Gaucher disease
Male Cancer
Prostatic carcinoma
Malignancy associate with noninfectious fever
Hodgkin lymphoma
Malignancy (kids)
ALL, medulloblastoma (cerebellum)
Metastases to bone
Prostate & breast > lung > thyroid
Metastases to brain
Lung > breast > genitourinary > melanoma > GI
Metasatses to liver
Colon»_space; stomach, pancreas
Mitochondrial inheritance
Disease occurs in both males and females, inherited through mother only
Mitral valve stenosis
Rheumatic heart disease
Mixed (UMN and LMN) motor neuron disease
Amyotrophic lateral sclerosis (ALS)
Myocarditis
Coxackie B
Nephrotic syndrome (adults)
Focal segmental glomerulosclerosis
Nephrotic syndreom (kids)
Minimal change disease
Neuron migration failure
Kallmann syndrome (hypogonadotropic hypogonadism and anosmia)
Nosocomial pneumonia
Klebsiella, E. Coli, Pseudomonas aeruginosa
Obstruction of male urinary tract
BPH
Opening snap
mitral stenosis
opportunistic infection in AIDS
pneumocystis jirovecii pneumonia
Osteomyelitis (most common)
S. aureus
Osteomyelitis in sickle cell disease
Salmonella
Osteomyelitis in IV drug use
S. aureus + Pseudomonas
Ovarian metastasis from gastric carcinoma or breast cancer
Krukenberg tumor (mucin-secreting signet-ring cells)
Ovarian tumor (benign, bilateral)
Serous cystadenoma
Ovarian tumor (malignant)
serous cystadenocarcinoma
Pancreatitis (acute)
Gallstones, alcohol
Pancreatitis (chronic)
Alcohol (adults) Cystic Fibrosis (kids)
Patient with ALL/CLL/AML/CML
ALL: child
CLL: adult > 60
AML: adult ~65
CML: adult 30-60
Pelvic inflammatory disease
Chlamydia trachomatis, Nisseria gonorrhoeae
Philadelphia chrmosome
t(9;22) (bcr-abl) - CML (sometimes ALL/AML)
Pituitary Tumor
Prolactinoma, somatotropic “acidophilic” adenoma
Primary amenorrhea
turner syndrome (45 X,O)
Primary bone tumor (adults)
Multiple Myeloma
Primary hyperaldosteronism
Adenoma of adrenal cortex
Primary hyperparathyroidism
Adenomas, hyperplasia, carcinoma
Primary liver cancer
Hepatocellular carcinoma (chronic hepatitis, cirrhosis, hemochromatosis, alpha1-antitrypsin deficiency)
Pulmonary HTN
COPD
Recurrent inflammation/thrombosis of small/medium vessels in extremities
Buerger disease (strongly associated with tobacco)
Renal Tumor
Renal cell carcinoma: associated with von Hippel-lindau and cigarette smoking; paraneoplastic syndromes (EPO, renin, PTH, ACTH)
Right heart failure due to a pulmonary cause
Cor pulmonale
S3 (protodiastolic gallop)
Increased ventricular filling (left to right shunt, mitral regurgitation, LV failure [CHF])
S4 (presystolic gallop)
Stiff/hypertrophic ventricle (aortic stenosis, restrictive cardiomyopathy)
Secondary hyperparathyroidism
Hypocalcemia of chronic kidney disease
Sexually transmitted disease
Chlamydia (usually coinfected with gonorrhea)
SIADH
small cell carcinoma of the lung
Site of diverticula
Sigmoid colon
Sites of atherosclerosis
Abdominal aorta > coronary artery > popliteal artery > carotid artery
Stomach cancer
adenocarcinoma
Somach ulcerations and high gastin levels
Zollinger-Ellison syndrome (gastrinoma of duodenum or pancreas
t(14;18)
Follicular Lymphomas (bcl-2 activation)
t(8;14)
Burkitt lymphoma (c-myc activation)
t(9;22)
Philadelphia chromosome, CML (bcr-abl fusion)
Temoporal arteritis
Risk of ipsilateral blindness due to thrombosis of ophthalmic artery; polymyalgia rhematica
Testicular tumor
seminoma (malignant, radiosensitive)
Thyroid cancer
Papillary carcinoma
Tumor in women
Leiomyoma (estrogen dependent, not precancerous)
Tumor of infancy
Hemangioma (usually regresses spontaneously by childhood)
Tumor of the adrenal medulla (adults)
Pheochromocytoma (usually benign)
Tumor of the adrenal medulla (kids)
Neuroblastoma (malignant)
Type of Hodgkin
Nodular sclerosis (vs. mixed cellularity, lymphocytic predominance, lymphocytic depletion)
Type of Non-Hodgkin
Diffuse large cell
UTI
E. Coli, Staphylcoccus saphrophyticus (young women)
Viral enchephalitis affection temporal lobe
HSV-1
Vitamin Deficiency (US)
Folate (pregnancy womena are at high risk)
- body only stores 3-4 months supply; prevents neural tube defects