Kety - Adoption

Question 1

What was the adoption study for bio?

Answer 1

Kety

Question 2

Aim of Kety

Answer 2

See if genetic basis for Sz

Question 3

Sample for Kety

Answer 3

• 34 patients from Danish Adoption Register
• 33 matched pairs controls (age, gender, age adopted, social class)

Question 4

How did kety group sz ppts?

Answer 4

• chronic
• acute
• borderline

Question 5

What did kety use to find family?

Answer 5

Danish family records

Question 6

How many relatives did kety track?

Answer 6

463

Question 7

How many psychiatrists in kety?

Answer 7

Panel of 4

Question 8

What did psychiatrists do in Kety?

Answer 8

Blind test (did not know if adopt or bio family member) on family members records to diagnose w sz using medical records

Question 9

Kety RESULTS sample vs control bio family

Answer 9

With Sz:
- Bio family of sample = 8.7%
- Bio family of control = 1.9%

Question 10

What % of bio family of sample had Sz in kety?

Answer 10

8.7%

Question 11

What % of bio family of control had Sz in kety?

Answer 11

1.9%

Question 12

Kety conclusion

Answer 12

There is a genetic component for sz

Question 13

Kety sample weakness

Answer 13

Ethnocentric to denmark

Question 14

Kety reliability strength

Answer 14

High IRR as panel of 4 psychiatrists increases reliability

Question 15

How does Kety reduce ppt variables?

Answer 15

Matched pairs age, gender, adoption age, social class

Question 16

What did Kety group sz diagnosis as?

Answer 16

“Sz Spectrum Disorder”

Question 17

Kety “catch all term” weakness

Answer 17

Grouping together as “Sz Spectrum Disorder” umbrella term, may not actually capture sz so cannot argue concordance, reduces validity

Question 18

Is kety replicable?

Answer 18

Easily replicable, has since repeated to obtain further results on genetics & sz