Ketogenesis Flashcards
Ketone bodies are
Acetone
Acetoacetate
Beta hydroxy butyrate
Fate of ketone bodies
Acetone exhaled
Acetoacetate beta hydroxy butyrate : extrahepatic tissues
And oxidised to acetyl co A
Acetyl co A derived from
Fatty acids
Pyruvate
Oxidation
Breakdown of aminoacids into ketone bodies
Transporter lipid
Dolichols
Extracellular and intracellular messengers
Eicosonoids and phosphatidylinositol derivatives
Fatty acids esterified with glycerol to form
Triacyl glycerol
Fatty acids are synthesised from
Acetyl co A
Prerequisite of fatty acid synthesis
Acetyl co A
ATP
NADPH
NADPH supplies
H atom
Fatty acid synthesis steps
1 formation of acetyl coA and NADPH
2 formation of malonyl co A from acetyl co A
3 reaction of fatty acid synthase complex
Acetyl co A transferred to cytoplasm as
Citrate
Acetyl co A condensed with oxaloacetate by
Citrate synthase
Citrate cleaved to acetyl coA by
Citrate lyase
Malate used to produce NADPH in cytosol by
Malic enzyme
Major source of acetyl co A in ruminants
Acetate