Ketogenesis Flashcards

1
Q

Ketone bodies are

A

Acetone
Acetoacetate
Beta hydroxy butyrate

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2
Q

Fate of ketone bodies

A

Acetone exhaled
Acetoacetate beta hydroxy butyrate : extrahepatic tissues
And oxidised to acetyl co A

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3
Q

Acetyl co A derived from

A

Fatty acids
Pyruvate
Oxidation
Breakdown of aminoacids into ketone bodies

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4
Q

Transporter lipid

A

Dolichols

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5
Q

Extracellular and intracellular messengers

A

Eicosonoids and phosphatidylinositol derivatives

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6
Q

Fatty acids esterified with glycerol to form

A

Triacyl glycerol

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7
Q

Fatty acids are synthesised from

A

Acetyl co A

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8
Q

Prerequisite of fatty acid synthesis

A

Acetyl co A
ATP
NADPH

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9
Q

NADPH supplies

A

H atom

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10
Q

Fatty acid synthesis steps

A

1 formation of acetyl coA and NADPH
2 formation of malonyl co A from acetyl co A
3 reaction of fatty acid synthase complex

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11
Q

Acetyl co A transferred to cytoplasm as

A

Citrate

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12
Q

Acetyl co A condensed with oxaloacetate by

A

Citrate synthase

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13
Q

Citrate cleaved to acetyl coA by

A

Citrate lyase

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14
Q

Malate used to produce NADPH in cytosol by

A

Malic enzyme

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15
Q

Major source of acetyl co A in ruminants

A

Acetate

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16
Q

Acetyl coA to malonyl co A

A

Acetyl co A carboxylase

17
Q

Prosthetic group in acetyl co A carboxylase

A

Biotin

18
Q

Rate limiting step in the synthesis of fatty acids

A

Malonyl coA synthesis