Katzung 12th ed - Chapter 49 - Acyclovir (2) Flashcards
1
Q
What is the basic structure of acyclovir?
A
It is a guanosine analogue.
2
Q
Name three viruses that are most susceptible to acyclovir.
A
HSV-1, HSV-2, VZV.
3
Q
What are some clinical uses of acyclovir?
A
Genital herpes, Herpes encephalitis, Shingles.
4
Q
Describe the toxicities of acyclovir.
A
Acyclovir is well-tolerated. It is sold over-the-counter as topical Zovirax. There can be nausea, vomiting, diarrhoea, headache.
5
Q
Clearance of acyclovir?
A
Renal. Glomerular filtration and tubular secretion.
6
Q
Half-life of acyclovir?
A
3-4 hours.
7
Q
What dose is given to patients with Shingles?
A
800mg five times a day.
