Karius - Sleep & EEG Flashcards
gene products that set up circadian rhythm
- CLK
- BMAL
- Per
- CRY
area of the brain where circadian rhythm is generated
suprachiasmatic nucleus
area of the brain that controls circadian rhythm and sleep induction/arousal
hypothalamus
3 stages of non-REM sleep
- 1
- 2
- deep
EEG findings during REM sleep
low amplitude, high frequency
most of sleep time is spent in
non-REM sleep
nucleus of the hypothalamus that’s impt in sleep induction
ventral preoptic area
what binds to DP on meningeal cells?
PGD2
what is released from DP cells of meningies?
adenosine
what receptoe does adenosine bind to in the VPO
2a
what area releases Ach into the geniculate body to induce REM sleep
lateral pontine tegmentum
where does the geniculate body send info to to induce REM sleep
occipital cortex
what induces muscle paralysis in REM sleep?
Locus Ceruleus
the lateral hypothalamus is one of the only sources of what in the brain?
Orexin A and B
what NT is released in the locus ceruleus to active LC neurons
histamine
LC neurons release what NT to suppress REM sleep?
NE
waves that occur during quiet wakefulness with eyes closed
alpha
origin of alpha waves
from occipital cortex
waves that occur while awake with eyes open
beta
origin of beta waves
frontal, parietal cortex
waves ass’d with attention/motor planning
gamma
waves ass’d with furstration and sleep
theta
slowest and largest waves
delta
waves that do not require connection btwn thalamus and ctx
delta
duration of first sleep cycle
70-100 min
later sleep cycle avg length
90 min
REM sleep is characterized by
rapid eye movement
- slow, rolling movements of eyes
- EMGs show mm activity
stage 1 (N1) sleep
- low voltage EEG
- slowing of EEG freq
stage 1 (N1) sleep
Stage 2 sleep is known as
true sleep
EMGs show v quiet mm activity
stage 2 (N2) sleep
- increasing EEG voltage
- slowing of EEG frequency
- sleep spindles
- K complexes
Stage 2 (N2) sleep
EEG sign that someone is truly asleep
sleep spindles
bursts of alpha-like activity
sleep spindles
- increasing EEG voltage
- slowing of frequency with prominent theta and delta waves
deep sleep
- rapid side-to-side eye movement
- EMG becomes v quiet
REM sleep
- rapid, low voltage EEG
- similar to beta waves
REM sleep