Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Resp II > Fitz - Antiviral Pharm > Flashcards

Fitz - Antiviral Pharm Flashcards

1
Q

2 drugs that tx influenza A only

A
  • amatadine

- rimatadine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

2 drugs that tx influenza A & B

A
  • oseltamivir

- zanamavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

drug used to tx RSV

A

ribavirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

nuraminidase inhibitors

A
  • oseltamivir

- zanamavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MOA: nuraminidase inhibitors

A

inhibition of neuraminidase leads to inability of virus to cut loose from the cell membrane and therefore inhibits viral spread

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

ROA: oseltamivir

A

oral

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

AE: oseltamivir

A

nausea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

ROA: zanamivir

A

inhaled

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

AE: zanamivir

A

bronchospasm in asthmatics

-avoid in asthmatics, COPDers, pts with resp dz

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

olstamivir inidications

A

tx and prevention of flu A & B in pts >/= 1 yo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

zanamivir indications

A

tx of flu A & B in pts >/= 7 yo & prevention in pts >/= 5 yo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

neuraminidase window of efficacy

A

w/ in 48 of first s/s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

adamantanes

A
  • amatadine

- rimantadine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

MOA: adamantanes

A

block M2 ion channel causing inhibition of endosome acidification and therefore the uncoating/maturation of the virus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

amatadine distribution and clearance

A
  • dist to CNS

- renal eliminiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

rimatadine distribution and clearance

A
  • no CNS dist

- mixed hepatic and renal clearance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

MOA: ribaverin

A

inhibition of viral mRNA synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

2 drugs used to tx HSV & VZV

A
  • acyclovir

- valacyclovir

19
Q

drug used for acyclovir resistance

A

foscarnet

20
Q

3 drugs used for CMV

A
  • ganciclovir
  • valganciclovir
  • foacarnet
21
Q

antiviral acyclic nucleoside are analogs of what nucelotides in the cell?

A

guanosine

22
Q

HSV/VZV enzyme required for initial transformation of drugs into nucleotides

A

thymadine kinase

23
Q

CMV enzyme required for inital transformation of drugs into nucleotides

A

UL97 kinase

24
Q

MOA: anti-viral NTTPs

A

terminate viral DNA elongation d/t lack of 3’-OH

25
Q

mutations of thymadine kinase or UL97 kinase result in

A

inability of drugs to become mono-phosphorlyated

26
Q

nucleoside esters are pro-drugs with _____ oral bioavailability

A

high

27
Q

valacyclovir gets de-acylated into

A

acyclovir

28
Q

acyclovir distribution and elimination

A
  • dist to CNS

- renal elminiation

29
Q

Acyclovir activity

A

HSV-1 >/= HSV-2&raquo_space; VZV ~ ABV

30
Q

acyclovir is NOT active against

A

CMV

31
Q

valacyclovir is NOT active against

A

EBV or CMV

32
Q

acyclovir + pro-drug indications

A
  • HSV encephalitis

- prevention of HSV or VZV reactivation in immunocompromised patients

33
Q

AEs: acyclovir

A
  • acute renal failure

- neurologic toxicity

34
Q

valganciclovir gets de-acylated into

A

ganciclovir

35
Q

ganciclovir dist and elim

A
  • CNS dist

- renal elim

36
Q

ganciclovir is active against

A

CMV&raquo_space; HSV-1,-2, and VZV

37
Q

ganciclovir indications

A

CMV retinitis and prophylaxis against CMV in immunocompromised pts

38
Q

AEs: ganciclovir (+ pro-drug)

A
  • bone marrow suppression (leunopenia)

- hematologic and renal toxicity

39
Q

MOA: foscarnet

A

independent inhibition of viral DNA polymerase

40
Q

foscarnet indicaitons

A
  • CMV retinitis

- acyclovir resistant HSV, VZV, and CMV infections

41
Q

AEs: Foscarnet

A
  • nephrotoxicity

- hypoCa, hypoMg

42
Q

foscarnet can accumulate in the

A

bone matrix

43
Q

down side of foscarnet PK

A

short T1/2 - need frequent injections

44
Q

foscarnet elim

A

renal

Resp II (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions