Fitz - Pharm of TB Flashcards
1
Q
MOA: INH
A
disrupts mycolic acid synthesis
2
Q
fxn of katG
A
mycobacterium TB enzyme utilized by INH to be converted into it’s active form
3
Q
fast metabolizers of INH
A
asians
4
Q
slow metabolizers of INH
A
white, black, hispanics
5
Q
two types of toxicities caused by INH
A
1) hepatic
2) neuro
6
Q
toxic metabolite in hepatoxicity of INH
A
N-acetylhydrazine
7
Q
s/s of hepatotoxicity caused by INH
A
- elevated liver enzymes
- jaundice
- hepatitis
8
Q
mechanism of INH induced neurotoxicity
A
depletion of pyidoxines and therefore decreased NT synthesis
9
Q
Vitamin B6
A
pyridoxine
10
Q
s/s of neurotoxicity caused by INH
A
- seizures
- neuropathy
11
Q
INH only works against _______________
A
mycobacterium tuberculosis
12
Q
MOA: Rifampin
A
- inhibition of prokaryotic gene transcription and downstream events
- gets intracellular organisms
13
Q
sub for rifampin in HIV pts
A
rifambutin
14
Q
RIF increases metabolism of these drugs
A
- HIV meds: protease inhibitors and non-nucleoside RT inhibitors
- OCs: increased risk of unplanned pregnancy
15
Q
AEs: RIF
A
- red/orange bodily secretions (tears, sweat, urine)
- induces CYP405 > increases metabolism of other drugs
