Journal club, workshop and intervention

Question 1

oral microbiota

Answer 1

several niches due to different environments
10/20% similar between individuals

• The oral microbiota consists of bacteria, archea, fungi, protozoa and viruses:
  o Commensal microbes (+ / 0)
  o Symbiotic microbes (+ / +)
  o Pathogenic microbes (+ / -)

Question 2

disturbances of oral microbiome

Answer 2

• age
• host/environment (genes, pregnancy, diet, etc.)
• habitat (O2, pH, nutrition, etc.)
• biofilm maturation

Question 3

colorectal cancer

Answer 3

fusobacterium can increase wnt signalling causing tumour proliferation after beging swallowed and adhering to colon epithelium

Question 4

rheumatoid arthritis

Answer 4

porphyromonas gingivalis can citrulinate proteins
these are very immunogenic and antibodies will form
cross-reactive antibodies against cintruinated alfa-enolase will cause rheuma