Joint Fluid Analysis - Parks Flashcards

1
Q

What three things should you inspect joint fluid for visually?

A

Color
Viscosity
Turbidity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What two things should you do ala bacteriology to a joint fluid sample?

A

gram stain and culture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What three things should you use with the microscope to view joint fluid?

A

wet films
cell stains
polarized light

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

(blank) is a brown-orange-yellow color that indicates old degenerating red cells from a previous hemorrhage

A

xanthochromia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cloudy joint fluid is full of (blank and blank)

A

neutrophils and protein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Why can an aspirate be both bloody and purulent?

A

the inflammation is necrosing the cells and releasing blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What does a WBC <2000 tell you?

A

you have a non-inflammatory infiltrate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What does a WBC 2000-75k tell you?

A

You have an inflammatory infiltrate that could be septic arthritis and needs further eval. Likely to be gout or RA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What does a WBC >100k tell you

A

definite septic arthritis!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What does a PMN >50% tell you?

A

some type of inflammatory infiltrate, check for septic arthritis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What does a PMN less than 50 tell you?

A

probably not inflammatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

T/F: Even with a white count of 75k the joint culture may still be negative

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What kinds of diseases will you see with a WBC 2000-75k?

A
RA
gout
pseudogout
reactive arthritis (Reitter's disease)
ankylosing spondylitis
rheumatic fever
TB
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What kinds of diseases will you see with a WBC <2000?

A

Degenerative joint disease/osteoarthritis
trauma
subsidiing or EARLY inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

T/F: bacterial infections from anywhere in the body may seed hematogenously to the joints

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

T/F: you can have septic arthritis without any redness or heat

A

true

17
Q

T/F: when tapping a joint, take out as much fluid as possible

A

true

18
Q

T/F: uncaught septic arthritis can lead to major bone and cartilage destruction

A

true

19
Q

What two other diseases besides septic arthritis can have a purulent looking tap?

A

gout and RA; but always think septic first

20
Q

What are the two ways that gout causes tissue injury and inflammation?

A
  1. uric acid crystal uptake by PMNs causes them to lyse and release lysosomal contents
  2. uric crystal uptake by PMNs causes release of proinflammatory cytokines
21
Q

WHich cytokines are released by PMNs in gout?

A

TNFa
IL6
IL1
IL8

22
Q

release of LTB4, free radicals, and (blank) from the injured joint brings more PMNs into the gouty area

A

prostaglandins

23
Q

Is a stat uric acid level sufficient for diagnosing gout?

A

No, you need to look under them microscope. Can have gout without systemic uricemia

24
Q

What shape are gout cyrstals?

A

needle like

25
Q

What joint is the first to be affected in 50% of primary gout cases?

A

1st. MTP joint

26
Q

In what percent of pts does the 1st MTP become affected in gout?

A

90%

27
Q

There is a 90% chance of an acute gout attack if chronic uric acid levels are above what?

A

10mg/dL

28
Q

What percent of patients have a normal uric acid level but still have gout?

A

7-8%

29
Q

What other diseases can also present with uricemia?

A

RA, pseudogout, and septic arthritis

30
Q

What is the cutoff for increased serum uric acid?

A

6.8mg/dL

31
Q

IN what percent of pts may serum uric acid be normal who still have gout?

A

25%

32
Q

Calcium pyrosphosphate deposition disease (pseudogout) has what shaped crystals?

A

rhomboid or square and positively birefringent

33
Q

What joints are involved in CPDD?

A

knees, wrists, elbows, shoulders, and ankles

34
Q

T/F: CPPD occurs after joint trauma

A

true

35
Q

The resulting pathology of the meniscus from CPDD is (blank)

A

chondrocalcinosis

36
Q

What three other joint unrelated diseases may also cause CPP deposition?

A
  1. hemachromotosis
  2. hyperPTH
  3. hypomagnesia