JIA Flashcards
Diagnosis by ARA
Onset before 16
Sx must persist min 6 weeks
Arthritis in 1 or more joints (defined as swelling within a joint or limitation in the ROM with joint pain or tenderness)
Exclusion of other diseases
Etiology
Autoimmune, multifactorial inheritance (genetics + environmental trigger), involvement of T-cells & HLA genes
Is there a lab test to diagnose JIA?
No.
When does a child get assigned to a subtype?
After 6 mo of active disease
What are the 7 subtypes?
Oligoarticular persistent and extended Seronegative Polyarticular Seropositive Polyarticular Systemic Psoriatric Enthesitis Undifferentiated
How many joints are affected in Oligoarticular JIA
4 or fewer (50% have only 1)
What joints are often affected with Oligoarticular JIA?
KNEE, ankle, wrist (often asymmetric joint involvement)
What is the most common kind of JIA?
Oligoarticular JIA
What other condition is common with Oligoarticular JIA?
Iridocyclitis (anterior uveitis) - may be asymptomatic
What is Persistent Oligoarticular JIA?
Affects no more than 4 joints throughout the course of the disease
What is Extended Oligoarticular JIA?
Affects more than 4 joints after the first 6 mo of the disease
How many joints need to be affected to be considered Polyarticular JIA?
5 or more joints
What joints are affected in Polyarticular JIA?
Knees, ankles, elbows, wrists, cervical spine and TMJ
What are the subtypes of Polyarticular JIA?
Seronegative (RF-) & Seropositive (RF+)
Peak ages and type of joint involvement in Seronegative Polyarticular JIA
2-4 & 6-12 y.o.
ASYMMETRIC
Peak ages and type of joint involvement in Seropositive Polyarticular JIA
Girls in late childhood/early adolescence.
SYMMETRIC - similar to adult RA
(wrists/small joints in hands/feet)
Severe constitutional symptoms of Systemic JIA
High Spiking fever Salmon colored rash (tunk/proximal extremities) Hepatosplenomegaly Pleuritis Pericarditis Lymphadenopathy
What is the life threatening syndrome associated with Systemic JIA?
MAS (macrophage activation system) - activation of T cells and macrophages leads to overwhelming inflammatory response