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WHO > Jham Special Stains and Markers > Flashcards

Jham Special Stains and Markers Flashcards

1
Q

α1 antichymotrypsin

A

Histiocytes

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2
Q

α subunit of S-100

A

Melanoma and neural tumors

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3
Q

AE1/AE3

A

LOW molecular weight keratin

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4
Q

Actin

A

smooth muscle (oh good, its a leio)

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5
Q

Stains Acidic mucopolysaccharides blue

A

Alcian blue

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6
Q

Bcl-1

A

Mantle cell lymphoma (along with Cyclin-D1)

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7
Q

Bcl-2

A

T and B-cells, follicular lymphoma, SFT

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8
Q

Ber-EP4

A

+ in BCC, - in ameloblastoma

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9
Q

What pigment is affected by bleach?

A

melanin. Hemosiderin remains

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10
Q

What in the world is a Bodian stain?

A

Stain for axons (neurofibroma) - axons stain magenta in a neuroma and bundles stain in a NF

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11
Q

Brown and Brenn

A

microorganisms: actinomycosis

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12
Q

Basement membrane of lupus

A

C3

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13
Q

Calponin

A

smooth muscle specific proteins ( good for myoepithelial cells)

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14
Q

CAM5.2

A

LOW molecular weight keratin

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15
Q

C-ANCA - what is it now known as?

A

cytoplasmic anti-neutrophil cytoplasmic antibodies

Indirect immunofluorescence test for Wegner Granulomatosis, now known as Granulomatosis with Polyangiitis

now known as: PR3-ANCA for proteinase-3

Should also order ELISA for PR3

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16
Q

P-ANCA - What is it know known as?

A

Perinuclear anti-neutrophil cytoplasmic antibodies

Now known as MPO-ANCA (myeloperoxidase)

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17
Q

CDX2

A

intestinal epithelium (intestinal adenocarcinoma)

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18
Q

CD1a

A

LCH

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19
Q

CD3

A

T-cell specific (+ in ALCL)

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20
Q

CD4 (two positive conditions)

A

mycosis fungoides, Angioummunoblastic T-cell lymphoma

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21
Q

CD5

A

T-cells, mantle cells, + in CLL/SLL with CD23, + in Mantle cells lymphoma, negative in MALT lymphoma

22
Q

CD7

A

T-cells

23
Q

CD10 (aka?)

A

Aka: CALLA

T-cells, follicular center B-cells (+ in follicular lymphoma, -ve in mantle cells) + in Burkitt, + in RCC

24
Q

CD11c

A

hairy cell leukemia

25
Q

CD13

A

macrophage, monocyte lineage

26
Q

CD15/30

A

Hodgkin Lymphoma (Reed-Sternberg cell)

27
Q

CD20 (aka, what it stains, 2 positive conditions)

A

aka Leu-26

Pan B-cell marker (not plasma cells)

“popcorn” cell in Hodgkin Lymphoma (non-classical RS cell negative for CD15 and CD30, positive for CD19, 20, 22, 79a, Bcl-6

+ in MALT lymphoma

28
Q

CD25

A

Hairy cell leukemia

29
Q

CD30

A

RS cell, activated T and B cells, + ALCL

30
Q

CD31

A

Endothelial cells, better for angiosarc than CD34

31
Q

CD34 (cells stained, and 4 relevant entities that stain positive or negative)

A

endothelial cells / vascular marker

Positive: SFT (aka: hemangiopericytoma), DFSP, Spindle cell lipoma

Negative: BFH

32
Q

CD45 (aka, cell types, positive/negative conditions)

A

aka: Leukocyte Common Antigen (LCA)

All leukocytes except plasma cells

Positive in leukemias, lymphomas

Negative: RS cells in Hodgkin

33
Q

CD56 (2 conditions)

A

Pos:
NK T-cell lymphoma (hole in palate)
some cells of MNETI

34
Q

CD68 (3 cell types, one positive tumor)

A

macrophages, histiocytes, osteoclast-like giant cells

pos: GCT

35
Q

CD70

A

RS cell in Hodgkin lymphoma

36
Q

CD79a

A

B-cells (including plasma cells)

Positive in Mantle cell, Follicular, and plasmacytoma

37
Q

CD99

A

Ewing sarcoma, synovial sarcoma, SFT, mesenchymal chondrosarcoma

38
Q

CD117 (aka, 3 conditions its associated w/)

A

aka c-kit

positive:
GIST
Adenoid cystic Ca

Negative:
PLGA

39
Q

CD138

A

Plasma cells (plasmablastic lymphoma, plasmacytoma)

40
Q

Mum1

A

Plasma cells (plasmablastic lymphoma, plasmacytoma)

41
Q

CD163

A

Monocyte / macrophage / histiocyte lineage

Positive in BFH, Xanthoma of bone

Negative in DFSP

42
Q

CD207

A

aka Langrin…LCH

43
Q

Which is more sensitive and specific: chromogranin or synaptophysin?

A

synapto (chromo used as a supplement)

44
Q

CK7

A

Sinonasal or lung mets (CK7+/CK20-)

Positive in synovial sarcoma (with AE1/AE3, CK1)

45
Q

CK14

A

oncocytic tumors

46
Q

CK20

A

merkel cell carcinoma, colon cancer, checking for mets (CK7-/CK20+)

47
Q

Congo Red

A

Amyloid (apple green birefringence on polarized light)

48
Q

Crystal violet

A

amyloid (metachromatic)

49
Q

Cyclin D-1

A

Mantle cell lymphoma

50
Q

Desmin

A

mesenchymal cells: skeletal and smooth muscle, negative in myofibromatosis

51
Q

Factor VIII

A

endothelial cell stain

52
Q

Factor XIIIa (2 pos, 1 neg)

A

Positive
BFH
DF

Negative
DFSP

WHO (7 decks)

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