High Yield / Jill & Kevin Flashcards
Normal LN IHC staining: 3 stains for normal mantle zone
CD20 (mature B cells), CD79a (immature B cells and plasma cells), BCL2 (antiapoptotic)
Normal LN IHC staining: 7 Germinal center
CD10, BCL6, CD79a, CD20, Ki67 (innermost), few CD3/CD5 T cells…*BCL2 should be negative in a normal germinal center
Classic Hodgkin Lymphoma IHC 3 stains
CD30 (RS Cells), CD15 (RS cells), MUM1
Give 5 examples of cells that are antigen presenting and thus MHC class 2 cells
found only on antigen-presenting cells (dendritic cells, mononuclear phagocytes, b cells, thymic epi cells, some endothelial cells.
Inheritance pattern, chromosome, and gene name for Peutz-Jegher
AD, chromo 19, STK11 (LKB1)
What are the 6 oral manifestations strongly associated with HIV infection?
Candidiasis, OHL, Linear ging erythemia, NUG/NUP, KS, non-Hodgkin lymphoma
What are the concentrically layered basophilic inclusions found a rare condition of the urinary tract? Whats the condition?
Michaelis-Gutmann bodies in malakoplakia (soft plaque in Greek)..thought to be the insufficient killing of bacteria by macrophages
Desmoplastic melanoma IHC
MelinA NEGATIVE is the key. Trichrome positive. S100 hit or miss. Other markers (MITF1,HMB45, Tyrosinase) all negative
What does a negative EMA for ASPS help rule out?
EMA is negative in ASPS, but positive in clear cell renal cell carcinoma, so helps rule out RCC
What doe the intercytoplasmic crystals in ASPS stain positive for?
PAS positive, distase resistant
Urinary VMA is elevated in patients with what 2 tumor types?
pheochromocytoma or neuroblastoma
Name 7 EBV associated tumors (a few are quite generic)
- Burkitt Lymphoma
- Nasopharyngeal carcinoma
- Hodgkin and Non-Hodgkin Lymphomas
- PTLD (Post transplant Lymphoproliferative disorder)
- Leiomyosarcoma
- T-cell lymphomas
- Lymphoepithelioma (Schmincke-Regaud tumor)
Two most common locations for a chordoma
clivus and sacrococcygeal region
What are 3 characteristic histology findings for chordoma?
- lobulated 2. fibrous septa 3.physaliferous (bubbles/vacuoles)
6 stains for chordoma
CK8, CK18, CK19, EMA, S100, Brachyury
RCC cell of origin and common mutations
proximal tube epithelium…HVL and short arm chromo 3
Burton line’s specific lead type
lead sulfide
What is the alternate name for a lymphoepithelioma?
Schmincke-Regaud tumor
What is the diagnosis for a vesiculo-bullous lesion with antibodies directed against the plakin family and a history of lymphoid disorder?
paraneoplastic pemphigus
Histology of a spindle cell population and a glanular component? Consider:
synovial sarcoma
When considering necrotizing sialometaplasia, but you dont see ulceration on the surface and most of the glands are necrotic, consider:
subacute necrotizing sialadenitis
When you see histo features of cartilagenous islands in a maxillary ridge growth:
cutright lesion (i dont think they’d kill you if you put chondroid choristoma)
