JC 2022-23

Question 1

Influence of locoregional lymph node aspiration cytology vs sentinel lymph node mapping and biopsy on disease stage assignment in dogs with integumentary mast cell tumors

Lapsely et al 2021. Vet Surg

Answer 1

• sentinel LN can differ from local regional LN up to 25% of the time
• very poor cytology results – better sampling technique?
• FNA the sentinel LN may be interesting

Question 2

Diagnostic accuracy of pre-treatment biopsy for grading soft tissue sarcomas in dogs.

Perry et al 2014. Vet Comp Oncol

Answer 2

• overall concordance rate = 59% –> there is a 41% risk of biopsy grade changing after removal
• biopsy has a high specificity (95%) for detecting a high grade tumour, but only 33% sensitive
• so can trust a high grade biopsy
• will need to be more skeptical on low grade –> 30% chance of being underestimated
• the biopsy/ tumour excision was not reviewed by one single pathologist (introduced inter-observer variation)

Question 3

Marginal Excision of Low-Grade Spindle Cell Sarcoma of Canine Extremities: 35 Dogs (1996–2006).

Stefanello et al 2008

Answer 3

• biggest takeaway = there is a 30% chance that a marginal resection will achieve complete margins
• follow-up time = min 6months, short for STS recurrence. Has a good follow-up plan but not carried out
• need to look at the censor data

Question 4

Survival analysis in dogs with urinary transitional cell carcinoma that underwent whole-body computed tomography at diagnosis

Iwasaki et al 2018

Answer 4

• CT is superior compared to AUS for those hard access regions (intrapelvic), esp if AUS is negative
• Sternal LN, bone mets, and urethral involvement = shorter survival time

Question 5

Risk factors and outcome in dogs with recurrent massive hepatocellular carcinoma: A Veterinary Society of Surgical Oncology case–control study

Lapsley et al 2021

Answer 5

• exicision margin is not associated with risk of recurrence
• median time to recurrence is around a year
• no sig difference between overall survival for those with or without recurrence
• elevation in liver enzyme may be used as a marker to detect recurrence

Question 6

Evaluation of the anti-tumour activity of Coriolus versicolor polysaccharopeptide (I’m-Yunity) alone or in combination with doxorubicin for canine splenic hemangiosarcoma

Gedney et al 2022

Answer 6

unlikely effective, possibly harmful
since the doxo + PSP group had a slightly worse outcome
female PSP did worse than female DOX

Question 7

Single Agent Polysaccharopeptide DelaysMetastases and Improves Survival in Naturally Occurring Hemangiosarcoma
Dorothy Cimino Brown and Jennifer Reetz 2012

Answer 7

poor study,