Canine MCT

Question 1

Cytologic Criteria for Mast Cell Tumor Grading in Dogs With Evaluation of Clinical Outcome
Camus et al 2016. Vet Path. U of Georgia

Answer 1

• high grade if poorly granulated
• or at least 2 of the 4: mitotic figures, binucleated or multinucleated cells, nuclear pleomorphism, or >50% anisokaryosis
• 88% sensitivity and 94% specificity

Question 2

Correlation of Nodal Mast Cells with Clinical Outcome in Dogs with Mast Cell Tumour and a Proposed Classification System for the Evaluation of Node Metastasis
Weishaar et al 2014. J Comp Path. CSU

Answer 2

Question 3

Retrospective outcome evaluation for dogs with surgically excised, solitary Kiupel high-grade, cutaneous mast cell tumours
Moore et al. 2019. Vet Comp Oncol, Australia

Answer 3

• those with stage I Kiupel high grade can have prolonged survival with surgery
• mitotic index and tumour size = prognostic
• overall MST = 1046 days, those that develop metastasis post-op = 451 days

Question 4

Adjuvant medical therapy provides no therapeutic benefit in the treatment of dogs with low-grade mast cell tumours and early nodal metastasis undergoing surgery
Marconato et al 2019. Vet Comp Oncol, Italy

Answer 4

• ## 42 had adjuvant tx, 31 did not