Jaundice in Adults

Question 0

[T/F]

Bilirubin found in the urine is unconjugated.

Answer 0

F

Question 1

Measurement of bilirubin: methods

Answer 1

Van den Bergh method: serum bilirubin

Urine dipstick test: urine bilirubin

Question 2

[T/F]

Unconjugated bilirubin is always bound to albumin in the serum, not found in urine.

Answer 2

T

Question 3

ALT/AST&raquo_space; ALP

hepatocellular or cholestatic?

Answer 3

Hepatocellular!

Question 4

ALP&raquo_space; ALT/AST

hepatocellular or cholestatic?

Answer 4

Cholestatic!

Question 5

Low albumin levels, acute or chronic?

Answer 5

Chronic, such as cirrhosis or cancer

Question 6

Causes of indirect hyperbilirubinemia

Answer 6

Hemolytic disorders
Drugs
Inherited disorders

Question 7

Defects in mutation in gene for multiple drug resistance protein 2
Altered excretion of bilirubin into ducts

Answer 7

Dublin-Johnson syndrome

Question 8

Impaired canalicular export of conjugated bilirubin

Answer 8

Rotor’s syndrome

Question 9

Hepatocellular causes of jaundice

Answer 9

Viral hepatitis
Alcohol hepatitis
Toxin/drug-induced
Ischemic hepatitis
Autoimmune hepatitis

Question 10

Causes of intrahepatic cholestasis

Answer 10

Viral hepatitis
Alcoholic hepatitis
Drug toxicity
Primary biliary cirrhosis
Primary sclerosing cholangitis
Vanishing bile duct syndrome
Inherited diseases
Pregnancy

Question 11

Causes of extrahepatic cholestasis

Answer 11

Malignancy
Benign causes: 
-choledocholithiasis
-postop biliary structure
-primary sclerosing cholangitis
-chronic pancreatitis
-AIDS cholangiopathy
-Mirizzi syndrome
-parasitic disease