Jaundice Flashcards
Unconjugated hyperbilirubinemia in a person without jaundice or known underlying hepatic dysfunction
Gilbert syndrome
congenital reduction of bilirubin conjugation in the liver (AR)
Red cell fragments on smear; unconjugated hyperbilirubinemia
hemolysis
In hemolysis, what is elevated besides bilirubin (unconjugated)
serum LDH and haptoglobin
jaundice, fever, fatigue, malaise, vomiting, anorexia, RUQ pain, clay colored stools
Hep A
Bad complications of chronic Hep B
cirrhosis and HEPATOCELLULAR CARCINOMA!!!! (responsible for 80% of hepatocell carc worldwide)
HbsAG
hepatitis b surface antigen
present in both acute and chronic infection.
detectable 1-10 weeks, peaks then disappears by 4-6 months
antiHBs
antibody to surface antigen
when seen without HbSAg, this means infection has resolved or patient got the vaccine
IGM anti HbC
hepB core antigen
presence = ACUTE INFECTION
when you only see surface antigen without HbcAg, it means you have chronic hep B
Treatment for Hep A and B
supportive care and symptomatic treatment; hospitalize if extensive liver damage
vaccines also recommended for children and high risk adults (travel, exposure, IV drug users, chronic liver dx)
most common cause of chronic liver dx in US
hep C; most prevalently affects those born between 1945 - 1965
Of those dx with hep C, _____% will develop chronic infection
60-80%
long term complications of chronic hep C
cirrhosis, hepatocellular carcinoma, hepatic decomp
Current leading cause for liver transplantation in the US
chronic hep C
Possible treatment for hep C
ribavirin and/or interferon
AST TO ALT ratio on alcohol abuse
> 2:1, with elevated GGT
