IV-Infusion - Pre Lecture Flashcards
What does an IV infusion entail?
Delivery of a drug at a slow constant rate of zero-order
What is another name for constant plasma concentration level?
Steady-state concentration (Css)
Why is a slow constant drug deliver considered effective?
Drug concentrations remains within the therapeutic window
Time to reach steady state is dependent on what factor?
elimination rate constant (K)
What variable can we use to determine time to reach steady-state?
Elimination half-life
What is an outcome of constant infusion rate?
Plasma concentration will remain at Css
What happens to the plasma concentration if infusion is stopped?
System will behave like an IV bolus
List the following variables on the graph
A: Css
B: Infusion stopped
C: Elimination phase
D: 1 half-life
E: 3 half-life
G: 5 half-life
Describe the components of a 1-COM model?
Zero order rate constant
What is the equation for Css?
What is infusion rate (variable)?
R
What is the base equation of an IV infusion?
Used for any point before Css
What is Css?
Rate of input is equal to rate of output
What is the base equation when an infusion is stopped and elimination process predominates?
How can loading dose be calculated?
