Exam 1: Equations Flashcards
1
Q
First order equations
A
ln C = lnCo - kt
C = Coe^-kt
2
Q
Half life
A
t1/2 = 0.693/k
3
Q
Clearance
A
Cl = Vdk = Dose/AUC
4
Q
AUC
A
AUC = (An-1 + An)/2 (tn – tn-1)
5
Q
Time at steady state
A
tss = t1/2 * 5
6
Q
Volume of distribution at steady state?
A
Vss = Vc +Vp
7
Q
Css
A
8
Q
1COM Vd
A
Vd = Vc
9
Q
Distributional half-life?
A
10
Q
Concentration in peripheral
A
11
Q
Drug amount in the body?
A
12
Q
Drug fraction in plasma
A
Abody= Vd *Cplasma
13
Q
Drug fraction in tissue
A
14
Q
Unbound drug concentration in plasma
A
15
Q
Unbound drug concentration in tissue
A
16
Q
Unbound drug concentration at ss
A
17
Q
Vdss
A
18
Q
Loading dose
A
19
Q
Oral concentration
A
20
Q
tmax
A
